# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3881393 | B | Inhibition of rat NHE3-mediated sodium-dependant hydrogen ion antiport in Opossum kidney cells preincubated in NH4Cl-HEPES buffer containing BCECF-AM dye followed by washout with ammonium free HEPES and subsequent addition of compound in presence of NHE1 antagonist EIPA by fluorescence assay | Rattus norvegicus | 179 | cell-based format | Patent Bioactivity Data | ||
2. | ALA3881394 | B | Inhibition of human NHE3-mediated sodium-dependant hydrogen ion antiport in Opossum kidney cells preincubated in NH4Cl-HEPES buffer containing BCECF-AM dye followed by washout with ammonium free HEPES and subsequent addition of compound in presence of NHE1 antagonist EIPA by fluorescence assay | Homo sapiens | 162 | cell-based format | Patent Bioactivity Data | ||
3. | ALA3881398 | F | Effect on sodium level in urine in Sprague-Dawley rat at 3 mg/kg administered via oral gavage measured after 16 hrs by gravimetric analysis relative to vehicle-treated control | Rattus norvegicus | 65 | organism-based format | Patent Bioactivity Data | ||
4. | ALA3881402 | F | Effect on phosphate level in urine in Sprague-Dawley rat at 3 mg/kg administered via oral gavage measured after 16 hrs by gravimetric analysis relative to vehicle-treated control | Rattus norvegicus | 65 | organism-based format | Patent Bioactivity Data | ||
5. | ALA4257109 | B | Inhibition of rat NHE3 expressed in OK cells assessed as reduction in Na+ dependent H+ antiport in presence of NHE1 inhibitor EIPA by BCECF-AM dye based fluorescence assay | Rattus norvegicus | 182 | cell-based format | Patent Bioactivity Data | ||
6. | ALA4257110 | B | Inhibition of human NHE3 expressed in OK cells assessed as reduction in Na+ dependent H+ antiport in presence of NHE1 inhibitor EIPA by BCECF-AM dye based fluorescence assay | Homo sapiens | 169 | cell-based format | Patent Bioactivity Data | ||
7. | ALA4257117 | F | In vivo inhibition of NHE3 in Sprague-Dawley rat assessed as inhibition of sodium absorption from intestinal lumen by measuring urinary sodium concentration at 3 mg/kg, po via gavage measured after 16 hrs relative to control | Rattus norvegicus | 65 | organism-based format | Patent Bioactivity Data | ||
8. | ALA4257120 | F | In vivo inhibition of NHE3 in Sprague-Dawley rat assessed as urinary potassium concentration at 3 mg/kg, po via gavage measured after 16 hrs relative to control | Rattus norvegicus | 65 | organism-based format | Patent Bioactivity Data |