| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3873737 | Functional | Inhibition of LPS/INF-gamma induced CXCL10 promoter dependent transcription activity in human MONO-MAC-6 cells measured after 4 hrs by luciferase reporter gene assay | Homo sapiens | 3 | ALA3872242 | cell-based format | Scientific Literature | |
| 2. | ALA3873739 | ADME | Effect on constitutive activity of EF-1alpha expressed in human MONO-MAC-6 cells up to 50 uM measured after 4 hrs by luciferase reporter gene assay | Homo sapiens | 4 | ALA3872242 | cell-based format | Scientific Literature | |
| 3. | ALA3873740 | Toxicity | Cytotoxicity against human MONO-MAC-6 cells up to 50 uM measured after 24 hrs by XTT assay | Homo sapiens | 4 | ALA3872242 | cell-based format | Scientific Literature | |
| 4. | ALA3873741 | Binding | Inhibition of NF-kappaB (unknown origin) expressed in LPS/INF-gamma-stimulated human MONO-MAC-6 cells measured after 4 hrs by luciferase reporter gene assay | Homo sapiens | 4 | ALA3872242 | cell-based format | Scientific Literature | |
| 5. | ALA3873742 | Binding | Inhibition of IRF (unknown origin) expressed in LPS/INF-gamma-stimulated human MONO-MAC-6 cells assessed as reduction in ISRE dependent transcription activity measured after 4 hrs by luciferase reporter gene assay | Homo sapiens | 4 | ALA3872242 | cell-based format | Scientific Literature | |
| 6. | ALA3873743 | Functional | Inhibition of human THP1 cells derived IL-8 promoter dependent transcription activity expressed in LPS/INF-gamma stimulated human MONO-MAC-6 cells measured after 4 hrs by luciferase reporter gene assay | Homo sapiens | 4 | ALA3872242 | cell-based format | Scientific Literature | |
| 7. | ALA3873744 | Binding | Inhibition of Stat1 (unknown origin) expressed in LPS/INF-gamma-stimulated human MONO-MAC-6 cells assessed as reduction in GAS dependent transcription activity measured after 4 hrs by luciferase reporter gene assay | Homo sapiens | 4 | ALA3872242 | cell-based format | Scientific Literature | |
| 8. | ALA3873746 | Functional | Down regulation of TNF-alpha mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 4 hrs by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature | |
| 9. | ALA3873748 | Functional | Down regulation of IL-6 mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 4 hrs by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature | |
| 10. | ALA3873750 | Functional | Down regulation of CLCX10 mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 4 hrs by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature | |
| 11. | ALA3873752 | Functional | Down regulation of COX-2 mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 4 hrs by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature | |
| 12. | ALA3873754 | Functional | Down regulation of CCL2 mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 4 hrs by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature | |
| 13. | ALA3873756 | Functional | Down regulation of IL-8 mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 4 hrs by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature | |
| 14. | ALA3873781 | Functional | Inhibition of IL-6 mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 16 hrs | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature | |
| 15. | ALA3873782 | Functional | Inhibition of TNF-alpha mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 16 hrs | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature | |
| 16. | ALA3873783 | Functional | Inhibition of IL-23 mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 16 hrs | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature | |
| 17. | ALA3873784 | Functional | Inhibition of CXCL1 mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 16 hrs | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature | |
| 18. | ALA3873785 | Functional | Inhibition of CXCL10 mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 16 hrs | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature | |
| 19. | ALA3873786 | Functional | Inhibition of CXCL11 mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 16 hrs | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature | |
| 20. | ALA3873787 | Functional | Inhibition of IL-8 mRNA expression in LPS/INF-gamma stimulated human MONO-MAC-6 cells at 30 uM preincubated for 1 hr followed by LPS/INF-gamma stimulation measured after 16 hrs | Homo sapiens | 1 | ALA3872242 | cell-based format | Scientific Literature |
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