| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3865245 | B | Inhibition of chymotrypsin like activity of rabbit 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 2 hrs by fluorescence-based assay | Oryctolagus cuniculus | 6 | assay format | Scientific Literature | ||
| 2. | ALA3865246 | B | Inhibition of trypsin like activity of rabbit 20S proteasome using Bz-Val-Gly-Arg-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 2 hrs by fluorescence-based assay | Oryctolagus cuniculus | 6 | assay format | Scientific Literature | ||
| 3. | ALA3865247 | B | Inhibition of caspase like activity of rabbit 20S proteasome using Ac-nLPnLD-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 2 hrs by fluorescence-based assay | Oryctolagus cuniculus | 6 | assay format | Scientific Literature | ||
| 4. | ALA3865248 | B | Inhibition of chymotrypsin like activity of mouse spleen 20S proteasome beta5i subunit using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 2 hrs by fluorescence-based assay | Mus musculus | 6 | single protein format | Scientific Literature | ||
| 5. | ALA3865249 | B | Inhibition of bovine alpha chymotrypsin using Ala-Ala-Phe-7-AMC as substrate measured for 10 mins by spectrophotometric analysis | Bos taurus | 6 | assay format | Scientific Literature | ||
| 6. | ALA3865251 | F | Cytotoxicity against human WE68 cells harboring wild type p53 assessed as reduction in cell viability after 48 hrs by 7AAD-staining based FACS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA3865252 | F | Cytotoxicity against human RD-ES cells harboring p53 mutant assessed as reduction in cell viability after 48 hrs by 7AAD-staining based FACS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA3865253 | F | Cytotoxicity against human KGN cells harboring wild type p53 assessed as reduction in cell viability after 48 hrs by 7AAD-staining based FACS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 9. | ALA3865254 | F | Cytotoxicity against p53 deficient human SKOV3 cells assessed as reduction in cell viability after 48 hrs by 7AAD-staining based FACS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 10. | ALA3865255 | F | Cytotoxicity against human MCF7 cells harboring wild type p53 assessed as reduction in cell viability after 48 hrs by 7AAD-staining based FACS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA3865256 | F | Cytotoxicity against human MDA-MB-468 cells harboring mutant p53 assessed as reduction in cell viability after 48 hrs by 7AAD-staining based FACS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 12. | ALA3865257 | F | Cytotoxicity against human NCI-H929 cells harboring wild type p53 assessed as reduction in cell viability after 48 hrs by 7AAD-staining based FACS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 13. | ALA3865258 | F | Cytotoxicity against human U266 cells harboring mutant p53 assessed as reduction in cell viability after 48 hrs by 7AAD-staining based FACS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 14. | ALA3865259 | T | Cytotoxicity against human MCF10A cells harboring wild type p53 assessed as reduction in cell viability after 48 hrs by 7AAD-staining based FACS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA3865260 | T | Cytotoxicity against human IMR90 cells harboring wild type p53 assessed as reduction in cell viability after 48 hrs by 7AAD-staining based FACS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 16. | ALA3865261 | T | Cytotoxicity against HNDF cells harboring wild type p53 assessed as reduction in cell viability after 48 hrs by 7AAD-staining based FACS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 17. | ALA3865262 | T | Cytotoxicity against human LCL cells harboring wild type p53 assessed as reduction in cell viability after 48 hrs by 7AAD-staining based FACS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 18. | ALA3865269 | B | Selectivity ratio of IC50 for caspase like activity of rabbit 20S proteasome to IC50 for chymotrypsin like activity of rabbit 20S proteasome | Oryctolagus cuniculus | 4 | assay format | Scientific Literature |
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