# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3878759 | B | Inhibition of TSPO in mouse HT22 cells assessed as protection against amyloid beta (1 to 42)-induced mitochondrial membrane potential loss by measuring recovery of mitochondrial membrane potential at 5 uM preincubated for 10 mins followed by amyloid beta (1 to 42) addition measured every 1 hr for 3 hrs by JC1 staining based fluorescence assay relative to control | Mus musculus | 59 | cell-based format | Scientific Literature | ||
2. | ALA3878760 | B | Inhibition of TSPO in mouse HT22 cells assessed as protection against amyloid beta (1 to 42)-induced mitochondrial membrane potential loss by measuring recovery of ATP production at 5 uM preincubated for 10 mins followed by amyloid beta (1 to 42) addition measured after 7 hrs by luciferase reporter gene assay relative to control | Mus musculus | 25 | cell-based format | Scientific Literature | ||
3. | ALA3878761 | T | Cytotoxicity against mouse HT22 cells assessed as cell viability at 5 uM after 24 hrs by MTT assay relative to control | Mus musculus | 22 | organism-based format | Scientific Literature | ||
4. | ALA3878762 | B | Inhibition of TSPO in mouse HT22 cells assessed as inhibition of amyloid beta (1 to 42)-induced toxicity at 5 uM after 24 hrs by MTT assay relative to control | Mus musculus | 10 | cell-based format | Scientific Literature | ||
5. | ALA3878763 | B | Inhibition of TSPO in mouse HT22 cells assessed as inhibition of amyloid beta (1 to 42)-induced ROS generation at 5 uM after 6 hrs by DCFDA staining based fluorescence assay relative to control | Mus musculus | 10 | cell-based format | Scientific Literature |