| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3854930 | B | Inhibition of human COT (66 to 395 residues) expressed in Sf21 cells using 5-Fluo-Ahx-AGAGSGQLIDSNleANSFVGTR-NH2 as substrate after 60 mins by caliper microfluidic mobility shift assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 2. | ALA3854933 | B | Inhibition of COT in LPS-stimulated human PBMC assessed as reduction in ERK1/2 phosphorylation incubated for 60 mins followed by LPS stimulation for 12 mins by flow cytometric analysis | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 3. | ALA3854934 | B | Inhibition of COT in LPS-stimulated human PBMC assessed as reduction in TNFalpha release incubated for 1 hr followed by stimulation with LPS for 4 hrs by HTRF assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 4. | ALA3854938 | P | Octanol-water partition coefficient, log P of the compound by shake-flask method | 11 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA3854939 | A | Clearance in wild type Sprague-Dawley rat plasma at 1 mg/kg, iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA3854940 | B | Inhibition of COT in LPS-stimulated human whole blood assessed as reduction in TNFalpha release incubated for 30 mins followed by stimulation with LPS for 3 hrs by HTRF assay | Homo sapiens | 7 | tissue-based format | Scientific Literature | ||
| 7. | ALA3854941 | P | Equilibrium solubility of the compound at pH 6.8 after 16 hrs by mass spectrometric analysis | 9 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA3854942 | P | Equilibrium solubility of the compound at pH 4 after 16 hrs by mass spectrometric analysis | 9 | small-molecule physicochemical format | Scientific Literature |
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