# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3864383 | B | Agonist activity at FFA1 receptor (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
2. | ALA3868427 | F | Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
3. | ALA4027543 | B | Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
4. | ALA4027546 | F | Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
5. | ALA4027549 | F | Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay relative to linoleic acid | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
6. | ALA4027594 | P | Lipophilicity, log P of the compound | 4 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA4027595 | P | Dissociation constant, pKa of the compound | 4 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA4027596 | A | Metabolic stability in mouse microsomes assessed as compound metabolized after 30 mins | Mus musculus | 4 | assay format | Scientific Literature | ||
9. | ALA4027597 | A | Metabolic stability in rat microsomes assessed as compound metabolized after 30 mins | Rattus norvegicus | 4 | assay format | Scientific Literature | ||
10. | ALA4027598 | A | Metabolic stability in dog microsomes assessed as compound metabolized after 30 mins | Canis lupus familiaris | 4 | assay format | Scientific Literature | ||
11. | ALA4027599 | A | Metabolic stability in human microsomes assessed as compound metabolized after 30 mins | Homo sapiens | 4 | assay format | Scientific Literature | ||
12. | ALA4027600 | A | Intrinsic clearance in human microsomes | Homo sapiens | 4 | assay format | Scientific Literature | ||
13. | ALA4027601 | A | Intrinsic clearance in human hepatocytes | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
14. | ALA4027602 | A | Clearance in type 2 diabetes patient | Homo sapiens | 3 | assay format | Scientific Literature | ||
15. | ALA4027603 | A | Volume of distribution in type 2 diabetes patient | Homo sapiens | 3 | assay format | Scientific Literature | ||
16. | ALA4027604 | P | Aqueous solubility of the compound at pH 7.4 | 4 | small-molecule physicochemical format | Scientific Literature | |||
17. | ALA4027611 | F | Antidiabetic activity in po dosed Zucker fa/fa rat assessed as reduction in blood glucose AUC administered daily for 21 days followed by OGTT at 1 hr after compound dosing and measured 60 mins post glucose challenge by oral glucose tolerance test | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
18. | ALA4027621 | A | Drug metabolism in rat hepatocytes assessed as O-dealkylation | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
19. | ALA4027622 | A | Drug metabolism in rat hepatocytes assessed as oxidation | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
20. | ALA4027623 | A | Drug metabolism in rat hepatocytes assessed as glucuronidation | Rattus norvegicus | 4 | cell-based format | Scientific Literature |