# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA857173 | B | Inhibitory activity against HIV-1 Integrase (HIV-1-IN) | Human immunodeficiency virus 1 | 47 | ALA1135718 | single protein format | Scientific Literature | |
2. | ALA702428 | B | Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50% | Human immunodeficiency virus 1 | 26 | ALA1131129 | single protein format | Scientific Literature | |
3. | ALA702983 | F | Compound concentration required to reduce the exponential growth of KB cells by 50% | Homo sapiens | 27 | ALA1131129 | cell-based format | Scientific Literature | |
4. | ALA702437 | F | Fold increase in protein-linked DNA breaks (PLDB) with respect to untreated controls. | Homo sapiens | 27 | ALA1131129 | assay format | Scientific Literature | |
5. | ALA715022 | F | Compound concentration required to reduce the exponential growth of MT-4 cells by 50% | Homo sapiens | 27 | ALA1131129 | cell-based format | Scientific Literature | |
6. | ALA866629 | F | Cytotoxicity against human PC3 cell line | Homo sapiens | 47 | ALA1138035 | cell-based format | Scientific Literature | |
7. | ALA866631 | F | Cytotoxicity against human LNCaP cell line | Homo sapiens | 49 | ALA1138035 | cell-based format | Scientific Literature | |
8. | ALA932181 | F | Antiinflammatory activity in mouse J774A.1 cells assessed as inhibition of lipopolysaccharide-induced TNFalpha production pretreated for 2 hrs at 10 uM before LPS challenge | Mus musculus | 17 | ALA1141592 | cell-based format | Scientific Literature | |
9. | ALA932182 | F | Antiinflammatory activity in mouse J774A.1 cells assessed as inhibition of lipopolysaccharide-induced IL6 production pretreated for 2 hrs at 10 uM before LPS challenge | Mus musculus | 7 | ALA1141592 | cell-based format | Scientific Literature | |
10. | ALA1005244 | F | Protection against beta-amyloid (25 to 35) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay | Rattus norvegicus | 10 | ALA1150624 | cell-based format | Scientific Literature | |
11. | ALA1005245 | F | Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay | Rattus norvegicus | 10 | ALA1150624 | cell-based format | Scientific Literature | |
12. | ALA952229 | A | Inhibition of human recombinant CYP3A4 in presence of reduced glutathione | Homo sapiens | 34 | ALA1141678 | single protein format | Scientific Literature | |
13. | ALA952230 | A | Inhibition of human recombinant CYP1A2 in presence of reduced glutathione | Homo sapiens | 34 | ALA1141678 | single protein format | Scientific Literature | |
14. | ALA952231 | A | Inhibition of human recombinant CYP2C9 in presence of reduced glutathione | Homo sapiens | 34 | ALA1141678 | single protein format | Scientific Literature | |
15. | ALA952232 | A | Inhibition of human recombinant CYP2D6 in presence of reduced glutathione | Homo sapiens | 34 | ALA1141678 | single protein format | Scientific Literature | |
16. | ALA952233 | A | Inhibition of human recombinant CYP2B6 in presence of reduced glutathione | Homo sapiens | 34 | ALA1141678 | single protein format | Scientific Literature | |
17. | ALA999387 | P | Stability assessed as decomposition at 25 uM and pH 7.4 after 30 mins | 34 | ALA1141678 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA999388 | A | Inhibition of human recombinant CYP1A2 | Homo sapiens | 21 | ALA1141678 | single protein format | Scientific Literature | |
19. | ALA999391 | A | Inhibition of human recombinant CYP2D6 | Homo sapiens | 7 | ALA1141678 | single protein format | Scientific Literature | |
20. | ALA961646 | P | Hydrolytic stability assessed as compound degradation at 2 mg in sodium dihydrogen phosphate buffered 0.3% sodium carboxymethylcellulose solution at pH 7.4 after 45 hrs by HPLC | 56 | ALA1153929 | small-molecule physicochemical format | Scientific Literature |