# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3871229 | B | Antagonist activity at 5-HT3A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of Ca2+ flux by Fluo-4-AM dye based FLIPR assay | Homo sapiens | 26 | ALA3870365 | cell-based format | Scientific Literature | |
2. | ALA3871230 | B | Selectivity ratio of IC50 for 5-HT3A receptor (unknown origin) expressed in HEK293 cells to EC50 for alpha7 nACh receptor (unknown origin) expressed in HEK293 cells | Homo sapiens | 26 | ALA3870365 | cell-based format | Scientific Literature | |
3. | ALA3878920 | B | Partial agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 at holding potential of -90 mV by whole-cell voltage clamp technique | Rattus norvegicus | 6 | ALA3877302 | cell-based format | Scientific Literature | |
4. | ALA3878921 | B | Intrinsic activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under the current curve at holding potential of -90 mV at 10 uM by whole-cell voltage clamp technique relative to acetylcholine | Rattus norvegicus | 6 | ALA3877302 | cell-based format | Scientific Literature | |
5. | ALA3878922 | B | Intrinsic activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as induction of peak current at holding potential of -90 mV at 10 uM by whole-cell voltage clamp technique relative to acetylcholine | Rattus norvegicus | 6 | ALA3877302 | cell-based format | Scientific Literature | |
6. | ALA3878925 | B | Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 measured for 2 mins by FLIPR assay | Rattus norvegicus | 34 | ALA3877302 | cell-based format | Scientific Literature | |
7. | ALA3878926 | A | Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins followed by addition of acetylcholine measured for 2 mins by Fluo-4AM dye based FLIPR assay | Homo sapiens | 34 | ALA3877302 | cell-based format | Scientific Literature | |
8. | ALA3878927 | A | Selectivity ratio of IC50 for human 5-HT3A expressed in HEK293 cells to EC50 for rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 | 33 | ALA3877302 | cell-based format | Scientific Literature | ||
9. | ALA3878931 | A | Metabolic stability in human microsomes assessed as compound remaining measured after 10 mins | Homo sapiens | 2 | ALA3877302 | assay format | Scientific Literature | |
10. | ALA3878932 | A | Metabolic stability in mouse microsomes assessed as compound remaining measured after 10 mins | Mus musculus | 2 | ALA3877302 | assay format | Scientific Literature | |
11. | ALA3878933 | A | Metabolic stability in rat microsomes assessed as compound remaining measured after 10 mins | Rattus norvegicus | 2 | ALA3877302 | assay format | Scientific Literature | |
12. | ALA3878934 | B | Displacement of [125I]Tyr54-alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes co-expressing human RIC3 measured after 2 hrs by gamma counting method | Rattus norvegicus | 2 | ALA3877302 | cell-based format | Scientific Literature | |
13. | ALA3878935 | B | Agonist activity at rat alpha1beta1deltaepsilon nAChR expressed in HEK293 cells for 2 mins by FLIPR assay | Rattus norvegicus | 2 | ALA3877302 | cell-based format | Scientific Literature | |
14. | ALA3878936 | B | Agonist activity at rat alpha3beta4 nAChR expressed in HEK293 cells for 2 mins by FLIPR assay | Rattus norvegicus | 2 | ALA3877302 | cell-based format | Scientific Literature | |
15. | ALA3878937 | B | Agonist activity at rat alpha4beta2 nAChR expressed in HEK293 cells for 2 mins by FLIPR assay | Rattus norvegicus | 2 | ALA3877302 | cell-based format | Scientific Literature | |
16. | ALA3878944 | B | Inhibition of human ERG by patch clamp assay | Homo sapiens | 2 | ALA3877302 | assay format | Scientific Literature | |
17. | ALA3878945 | B | Partial agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 at 10 uM and holding potential of -90 mV in presence of alpha7 nAChR antagonist MLA by whole-cell voltage clamp technique | Rattus norvegicus | 1 | ALA3877302 | cell-based format | Scientific Literature | |
18. | ALA3878946 | A | Inhibition of human CYP3A4 using BFC as substrate | Homo sapiens | 1 | ALA3877302 | single protein format | Scientific Literature | |
19. | ALA3878947 | A | Inhibition of human CYP3A4 using BZR as substrate | Homo sapiens | 1 | ALA3877302 | single protein format | Scientific Literature | |
20. | ALA3878948 | A | Inhibition of human CYP1A2 | Homo sapiens | 1 | ALA3877302 | single protein format | Scientific Literature |