# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3882744 | B | Inhibition of CYP17 in human testicular microsomes using 17alpha-hydroxypregnenolone as substrate assessed as decrease in DHEA levels after 90 mins by ELISA | Homo sapiens | 409 | assay format | Patent Bioactivity Data | ||
2. | ALA3882745 | B | Inhibition of CYP17 in human testicular microsomes using 17alpha-hydroxypregnenolone as substrate assessed as decrease in DHEA levels at 10 nM after 90 mins by ELISA relative to control | Homo sapiens | 409 | assay format | Patent Bioactivity Data | ||
3. | ALA3882747 | B | Inhibition of CYP17 in human H295R cells assessed as decrease in testosterone levels after 24 hrs by ELISA | Homo sapiens | 409 | cell-based format | Patent Bioactivity Data | ||
4. | ALA3882749 | A | Half life in human liver microsomes at 1 uM by LC-MS/MS analysis | Homo sapiens | 409 | tissue-based format | Patent Bioactivity Data | ||
5. | ALA3882750 | B | Inhibition of Sprague-Dawley rat adrenal mitochondrial CYP11B assessed as decrease in conversion of 11-deoxycortisol to cortisol at 100 nM incubated for 60 mins by ELISA relative to control | Rattus norvegicus | 409 | protein format | Patent Bioactivity Data | ||
6. | ALA3882751 | B | Inhibition of human CYP21 transfected in HEK293 cells assessed as decrease in conversion of progesterone to 11-deoxycorticosterone at 100 nM preincubated for 5 hrs followed by progesterone addition measured after 20 hrs by ELISA relative to control | Homo sapiens | 407 | cell-based format | Patent Bioactivity Data | ||
7. | ALA3882752 | B | Inhibition of CYP17 in human testicular microsomes using 17alpha-hydroxypregnenolone as substrate assessed as decrease in DHEA levels at 1 nM after 90 mins by ELISA relative to control | Homo sapiens | 289 | assay format | Patent Bioactivity Data | ||
8. | ALA3882753 | B | Inhibition of human CYP21 transfected in HEK293 cells assessed as decrease in conversion of progesterone to 11-deoxycorticosterone preincubated for 5 hrs followed by progesterone addition measured after 20 hrs by ELISA | Homo sapiens | 290 | cell-based format | Patent Bioactivity Data |