| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3861286 | B | Inhibition of His-tagged full length Hsp90/GST-tagged Cdc37 middle domain (unknown origin) interaction at 50 uM after 1 hr by TR-FRET assay relative to control | Homo sapiens | 24 | ALA3860070 | assay format | Scientific Literature | |
| 2. | ALA3861288 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay | Homo sapiens | 24 | ALA3860070 | cell-based format | Scientific Literature | |
| 3. | ALA3861289 | F | Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay | Homo sapiens | 24 | ALA3860070 | cell-based format | Scientific Literature | |
| 4. | ALA3861290 | F | Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay | Homo sapiens | 24 | ALA3860070 | cell-based format | Scientific Literature | |
| 5. | ALA4396409 | A | Induction of apoptosis in TNFalpha-treated human HepG2 cells assessed as normal cells at 2 uM incubated for 10 hrs by FITC Annexin V and propidium iodide staining based flow cytometric analysis (Rvb = 88.37%) | Homo sapiens | 3 | ALA4393721 | cell-based format | Scientific Literature | |
| 6. | ALA4396410 | B | Binding affinity to GFP-Nur77 (unknown origin) expressed in human HepG2 cells cotransfected with mCherry-p62/SQSTM1 assessed as co-localization with p62/SQSTM1 in cytoplasm in presence of TNFalpha by DAPI staining based confocal microscopic analysis | Homo sapiens | 3 | ALA4393721 | cell-based format | Scientific Literature | |
| 7. | ALA4396411 | B | Binding affinity to recombinant human N-terminal His-tagged Nur77 LBD (367 to 598 residues) expressed in Escherichia coli BL21(DE3) incubated for 30 secs by fluorescence quenching assay | Homo sapiens | 25 | ALA4393721 | assay format | Scientific Literature | |
| 8. | ALA4396413 | F | Antiinflammatory activity in human HepG2 cells assessed as inhibition of TNFalpha-induced IkappaBalpha degradation at 2 uM pretreated for 1 hr followed by TNFalpha addition and measured after 30 mins by Western blot analysis | Homo sapiens | 25 | ALA4393721 | cell-based format | Scientific Literature | |
| 9. | ALA4396414 | B | Binding affinity to Myc-Nur77 (unknown origin) expressed in human HepG2 cells co-transfected with Flag tagged TRAF2 assessed as effect on protein interaction with TRAF2 at 2 uM incubated for 1 hr in presence of TNFalpha by co-immunoprecipitation assay | Homo sapiens | 3 | ALA4393721 | cell-based format | Scientific Literature | |
| 10. | ALA4396415 | A | Induction of apoptosis in TNFalpha-treated human HepG2 cells assessed as PARP cleavage at 2 uM incubated for 10 hrs by Western blot analysis | Homo sapiens | 3 | ALA4393721 | cell-based format | Scientific Literature | |
| 11. | ALA4396416 | A | Induction of apoptosis in TNFalpha-treated human HepG2 cells assessed as non-viable apoptotic cells at 2 uM incubated for 10 hrs by FITC Annexin V and propidium iodide staining based flow cytometric analysis (Rvb = 6.65%) | Homo sapiens | 3 | ALA4393721 | cell-based format | Scientific Literature | |
| 12. | ALA4396417 | A | Induction of apoptosis in TNFalpha-treated human HepG2 cells assessed as viable apoptotic cells at 2 uM incubated for 10 hrs by FITC Annexin V and propidium iodide staining based flow cytometric analysis (Rvb = 3.69%) | Homo sapiens | 3 | ALA4393721 | cell-based format | Scientific Literature | |
| 13. | ALA4396418 | A | Induction of apoptosis in TNFalpha-treated human HepG2 cells assessed as necrotic cells at 2 uM incubated for 10 hrs by FITC Annexin V and propidium iodide staining based flow cytometric analysis (Rvb = 1.29%) | Homo sapiens | 3 | ALA4393721 | cell-based format | Scientific Literature | |
| 14. | ALA4669986 | A | Cytotoxicity against BALB/c mouse T cell assessed as reduction in cell viability after 48 hrs by CCK8 assay | Mus musculus | 44 | ALA4665764 | tissue-based format | Scientific Literature | |
| 15. | ALA4669987 | F | Antiproliferative activity against Con A-induced BALB/c mouse T cell after 48 hrs by CCK8 assay | Mus musculus | 44 | ALA4665764 | tissue-based format | Scientific Literature | |
| 16. | ALA4669988 | U | Selectivity index, ratio of CC50 for cytotoxicity against BALB/c mouse T cell to IC50 for antiproliferative activity against Con A-induced BALB/c mouse T cell | Mus musculus | 44 | ALA4665764 | tissue-based format | Scientific Literature |
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