| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA643700 | B | Antilog of the difference between pD2 of Alpha-2 adrenergic receptor and pD2 of Alpha-1 adrenergic receptor | 8 | ALA1135400 | protein format | Scientific Literature | ||
| 2. | ALA643213 | F | Ability to activate human alpha-1D receptor expressed in rat-1 fibroblasts as calcium mobilization through Gq coupled PLC pathway relative to phenylephrine response | Homo sapiens | 9 | ALA1135838 | assay format | Scientific Literature | |
| 3. | ALA643412 | F | Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway | 30 | ALA1135838 | assay format | Scientific Literature | ||
| 4. | ALA643027 | B | pD2 is -log ED50 required to produce 50% inhibition of the twitch response in rat vas deferens (intrinsic activity in presence of clonidine) for Alpha-2 adrenergic receptor | 6 | ALA1135400 | tissue-based format | Scientific Literature | ||
| 5. | ALA640225 | B | Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat cortex membrane | Rattus norvegicus | 13 | ALA1135400 | assay format | Scientific Literature | |
| 6. | ALA643867 | B | Inhibition of Alpha-1 adrenergic receptor twitch response in rat vas deferens in presence of cirazoline, pD2 is -log ED50 | Rattus norvegicus | 12 | ALA1135400 | tissue-based format | Scientific Literature | |
| 7. | ALA649811 | B | Relative binding affinity for Alpha-2 adrenergic receptor and I2 imidazoline binding site (Antilog of the difference between pKi) | 13 | ALA1135400 | assay format | Scientific Literature | ||
| 8. | ALA647826 | F | Ability to activate cloned human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through Gq coupled PLC pathway expressed as percent of phenylephrine (40 uM) response | 25 | ALA1135838 | assay format | Scientific Literature | ||
| 9. | ALA650229 | F | Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway | 30 | ALA1135838 | assay format | Scientific Literature | ||
| 10. | ALA652785 | F | Activation of human alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway expressed as percent of phenylephrine (40 um) response; No data | Homo sapiens | 18 | ALA1135838 | assay format | Scientific Literature | |
| 11. | ALA651230 | F | Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway | 30 | ALA1135838 | assay format | Scientific Literature | ||
| 12. | ALA841870 | B | Displacement of [3H]idazoxan from imidazoline receptor I-2 binding sites in rabbit kidney membrane | Oryctolagus cuniculus | 13 | ALA1135400 | cell membrane format | Scientific Literature | |
| 13. | ALA3056380 | B | Binding affinity to I2 imidazoline binding site (unknown origin) | Homo sapiens | 25 | ALA3046493 | assay format | Scientific Literature | |
| 14. | ALA3056381 | B | Binding affinity to I1 imidazoline binding site in Rattus norvegicus (rat) PC12 cells | Rattus norvegicus | 25 | ALA3046493 | cell-based format | Scientific Literature | |
| 15. | ALA3855949 | B | Displacement of [3H]-RX 821002 from alpha2-AR in Sprague-Dawley rat brain membranes after 30 mins by liquid scintillation counting | Rattus norvegicus | 9 | ALA3853360 | cell membrane format | Scientific Literature | |
| 16. | ALA3855950 | B | Displacement of [125I]-p-iodoclonidine from I1 receptor imidazoline binding site in Sprague-Dawley rat kidney cell membranes after 30 mins by liquid scintillation counting | Rattus norvegicus | 9 | ALA3853360 | cell-based format | Scientific Literature | |
| 17. | ALA3855951 | B | Displacement of [3H]-2-BFI from I2 receptor imidazoline binding site in Sprague-Dawley rat brain membranes after 30 mins by liquid scintillation counting | Rattus norvegicus | 9 | ALA3853360 | cell membrane format | Scientific Literature | |
| 18. | ALA3855952 | A | Agonist activity at human alpha2a-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis | Homo sapiens | 1 | ALA3853360 | cell-based format | Scientific Literature | |
| 19. | ALA3855953 | B | Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis | Homo sapiens | 5 | ALA3853360 | cell-based format | Scientific Literature | |
| 20. | ALA3855954 | B | Agonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis | Homo sapiens | 5 | ALA3853360 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!