# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3873577 | B | Inhibition of human recombinant mPGES-1 expressed in CHO cells assessed as reduction in conversion of PGH2 to PGE2 incubated for 10 mins followed by substrate addition measured after 1 min in presence of GSH | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
2. | ALA4181289 | B | Inhibition of guinea pig mPGES1 | Cavia porcellus | 2 | assay format | Scientific Literature | ||
3. | ALA4181290 | B | Inhibition of recombinant human mPGES1 expressed in CHO cells using PGH2 as substrate pretreated for 10 mins followed by substrate addition measured after 1 min | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
4. | ALA4181291 | B | Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta induced PGE2 production pretreated for 30 mins followed by IL-1beta addition measured after 16 to 20 hrs by HTRF method | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
5. | ALA4181292 | A | Stability in human liver microsomes assessed as parent compound remaining at 1 uM after 60 mins by LC-MS/MS analysis | Homo sapiens | 29 | microsome format | Scientific Literature | ||
6. | ALA4181293 | A | Stability in guinea pig liver microsomes assessed as parent compound remaining at 1 uM after 60 mins by LC-MS/MS analysis | Cavia porcellus | 29 | microsome format | Scientific Literature | ||
7. | ALA4181294 | B | Inhibition of mPGES1 in human whole blood assessed as inhibition of LPS-induced PGE2 production measured after 20 to 24 hrs | Homo sapiens | 7 | single protein format | Scientific Literature | ||
8. | ALA4181295 | A | Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-Hydroxy-testosterone formation at 10 uM measured after 20 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 8 | microsome format | Scientific Literature | ||
9. | ALA4181296 | A | Inhibition of CYP2C9 in human liver microsomes assessed as reduction in 4hydroxy-diclofenac formation at 10 uM measured after 20 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 8 | microsome format | Scientific Literature | ||
10. | ALA4181297 | A | Inhibition of CYP2C19 in human liver microsomes assessed as reduction in 4-Hydroxy-mephenytoin formation at 10 uM measured after 40 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 8 | microsome format | Scientific Literature | ||
11. | ALA4181298 | P | Intrinsic solubility of the compound | 26 | small-molecule physicochemical format | Scientific Literature | |||
12. | ALA4181299 | B | Inhibition of human ERG expressed in HEK293 cells at 10 uM by patch clamp method relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
13. | ALA4181300 | B | Inhibition of mPGES1 in guinea pig whole blood assessed as inhibition of LPS-induced PGE2 production measured after 20 to 24 hrs | Cavia porcellus | 2 | assay format | Scientific Literature | ||
14. | ALA4181301 | B | Inhibition of rat mPGES1 at 10 uM relative to control | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
15. | ALA4181302 | B | Inhibition of mouse mPGES1 at 10 uM relative to control | Mus musculus | 2 | single protein format | Scientific Literature | ||
16. | ALA4181303 | A | Inhibition of COX1 in human U937 cells at 10 uM using arachidonic acid as substrate pretreated for 15 mins followed by substrate addition measured after 5 mins relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA4181304 | A | Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 cells at 10 uM using arachidonic acid as substrate pretreated for 15 mins followed by substrate addition measured after 5 mins relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA4181305 | B | Inhibition of mPGES2 in human THP1 cells assessed as reduction in A23187-stimulated PGE2 production at 10 uM relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA4181306 | B | Inhibition of cPGES in human U937 cells assessed as arachidonic acid-induced PGE2 production at 10 uM relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA4181307 | A | Stability in rat liver microsomes assessed as parent compound remaining at 1 uM after 60 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | microsome format | Scientific Literature |