# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3880020 | B | Inhibition of human TRPM5 transfected in HEK293 cells assessed as inhibition of ATP-mediated calcium mobilization by Calcium3 dye-based FLIPR assay | Homo sapiens | 68 | ALA3879891 | cell-based format | Patent Bioactivity Data | |
2. | ALA3880021 | B | Inhibition of human TRPM5 transfected in HEK293 cells assessed as inhibition of KCl-stimulated membrane potential by FLIPR assay | Homo sapiens | 68 | ALA3879891 | cell-based format | Patent Bioactivity Data | |
3. | ALA3880022 | B | Activation of TRPM5 in mouse GLUTag cells assessed as induction of 0.1 mM glucose-mediated GLP-1 secretion at 0.1 uM to 10 M after 2 hrs by ELISA | Mus musculus | 1 | ALA3879891 | cell-based format | Patent Bioactivity Data | |
4. | ALA3880023 | B | Activation of TRPM5 in mouse GLUTag cells assessed as induction of 0.3 mM glucose-mediated GLP-1 secretion after 2 hrs by ELISA | Mus musculus | 1 | ALA3879891 | cell-based format | Patent Bioactivity Data | |
5. | ALA3880024 | B | Activation of TRPM5 in Sprague-Dawley rat primary islets assessed as induction of 3 mM glucose-mediated insulin secretion at 1 to 10 uM after 3 hrs by ELISA | Rattus norvegicus | 1 | ALA3879891 | single protein format | Patent Bioactivity Data | |
6. | ALA3880025 | B | Activation of TRPM5 in Sprague-Dawley rat primary islets assessed as induction of 12 mM glucose-mediated insulin secretion after 3 hrs by ELISA | Rattus norvegicus | 1 | ALA3879891 | single protein format | Patent Bioactivity Data | |
7. | ALA3880026 | B | Activation of TRPM5 in SV40 expressing transgenic mouse Beta-TC-6 cells assessed as induction of 0.3 mM glucose-mediated insulin secretion at 0.03 to 3 uM after 2 hrs by ELISA | Mus musculus | 1 | ALA3879891 | assay format | Patent Bioactivity Data | |
8. | ALA3880027 | B | Activation of TRPM5 in SV40 expressing transgenic mouse Beta-TC-6 cells assessed as induction of 1 mM glucose-mediated insulin secretion after 2 hrs by ELISA | Mus musculus | 1 | ALA3879891 | assay format | Patent Bioactivity Data |