# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3857085 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 8 | ALA3856205 | tissue-based format | Scientific Literature | |
2. | ALA3857086 | B | Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay | Homo sapiens | 28 | ALA3856205 | single protein format | Scientific Literature | |
3. | ALA3857087 | B | Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells at 10 uM after 24 hrs by beta-galactosidase/luciferase reporter gene assay relative to control | Homo sapiens | 28 | ALA3856205 | cell-based format | Scientific Literature | |
4. | ALA3857088 | B | Inhibition of fluorescien-conjugated coactivator PGC1a binding to ERRalpha (unknown origin) after 1 hr by TR-FRET assay | Homo sapiens | 8 | ALA3856205 | single protein format | Scientific Literature | |
5. | ALA3857089 | A | Inhibition of CYP1A2 in human liver microsomes assessed as remaining activity by measuring phenacetin O-deethylase activity at 10 uM pre-incubated for 5 mins followed by NADPH regenerating system addition by LC-MS/MS analysis relative to control | Homo sapiens | 8 | ALA3856205 | tissue-based format | Scientific Literature | |
6. | ALA3857090 | B | Inhibition of fluorescien-conjugated coactivator PGC1a binding to ERRbeta (unknown origin) after 1 hr by TR-FRET assay | Homo sapiens | 8 | ALA3856205 | single protein format | Scientific Literature | |
7. | ALA3857091 | B | Inhibition of fluorescien-conjugated coactivator PGC1a binding to ERalpha (unknown origin) after 1 hr by TR-FRET assay | Homo sapiens | 8 | ALA3856205 | single protein format | Scientific Literature | |
8. | ALA3857092 | B | Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assay | Homo sapiens | 8 | ALA3856205 | cell-based format | Scientific Literature | |
9. | ALA3857093 | A | Inhibition of CYP2C9 in human liver microsomes assessed as remaining activity by measuring tolbutamide 4-hydroxylase activity at 10 uM pre-incubated for 5 mins followed by NADPH regenerating system addition by LC-MS/MS analysis relative to control | Homo sapiens | 8 | ALA3856205 | tissue-based format | Scientific Literature | |
10. | ALA3857094 | A | Inhibition of CYP2C19 in human liver microsomes assessed as remaining activity by measuring S-mephenytoin 4-hydroxylase activity at 10 uM pre-incubated for 5 mins followed by NADPH regenerating system addition by LC-MS/MS analysis relative to control | Homo sapiens | 8 | ALA3856205 | tissue-based format | Scientific Literature | |
11. | ALA3857095 | A | Inhibition of CYP2D6 in human liver microsomes assessed as remaining activity by measuring dextromethorphan O-demethylase activity at 10 uM pre-incubated for 5 mins followed by NADPH regenerating system addition by LC-MS/MS analysis relative to control | Homo sapiens | 8 | ALA3856205 | tissue-based format | Scientific Literature | |
12. | ALA3857096 | A | Inhibition of CYP3A4 in human liver microsomes assessed as remaining activity by measuring midazolam 1'-hydroxylase activity at 10 uM pre-incubated for 5 mins followed by NADPH regenerating system addition by LC-MS/MS analysis relative to control | Homo sapiens | 8 | ALA3856205 | tissue-based format | Scientific Literature | |
13. | ALA3857097 | A | Metabolic stability in dog liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of NADPH by LC-MS/MS analysis | Canis lupus familiaris | 8 | ALA3856205 | tissue-based format | Scientific Literature | |
14. | ALA3857098 | A | Metabolic stability in rat liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 8 | ALA3856205 | tissue-based format | Scientific Literature | |
15. | ALA3857099 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 8 | ALA3856205 | tissue-based format | Scientific Literature | |
16. | ALA3857100 | A | Permeability of the compound in PBS at pH 7.4 at 10 uM after 5 hrs by LC-MS/MS analysis | 8 | ALA3856205 | assay format | Scientific Literature | ||
17. | ALA4413805 | B | Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assay | Homo sapiens | 36 | ALA4411321 | single protein format | Scientific Literature | |
18. | ALA4413806 | B | Inverse agonist activity at CMX-gal4-fused ERRgamma (unknown origin) transfected in human AD293 cells co-expressing CMV-beta galactosidase assessed as effect on beta-galactosidase activity at 10 uM after 24 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 36 | ALA4411321 | cell-based format | Scientific Literature | |
19. | ALA4413807 | B | Binding affinity to ERRalpha (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assay | Homo sapiens | 16 | ALA4411321 | single protein format | Scientific Literature | |
20. | ALA4413808 | B | Binding affinity to ERRbeta (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assay | Homo sapiens | 16 | ALA4411321 | single protein format | Scientific Literature |