# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3863932 | F | Inhibition of Shigella dysenteriae Shiga toxin-induced mortality in Balb/c mouse exposed to 5 x LD50 Shigella toxin assessed as increase in mouse survival at 2 mM, ip preincubated with Stx for 1 hr measured after 0 to 14 days | Mus musculus | 6 | organism-based format | Scientific Literature | ||
2. | ALA3863933 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit | Shigella dysenteriae | 23 | single protein format | Scientific Literature | ||
3. | ALA3863934 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-based thermal shift assay | Shigella dysenteriae | 20 | single protein format | Scientific Literature | ||
4. | ALA3863935 | T | Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by neutral red uptake assay | Chlorocebus sabaeus | 32 | cell-based format | Scientific Literature | ||
5. | ALA3863936 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay relative to untreated control | Shigella dysenteriae | 6 | cell-based format | Scientific Literature | ||
6. | ALA3863937 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by MTT assay relative to untreated control | Shigella dysenteriae | 6 | cell-based format | Scientific Literature | ||
7. | ALA3863938 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by LDH release assay relative to untreated control | Shigella dysenteriae | 6 | cell-based format | Scientific Literature | ||
8. | ALA3863939 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as protection of cell membrane integrity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by LDH release assay relative to untreated control | Shigella dysenteriae | 6 | cell-based format | Scientific Literature | ||
9. | ALA3863940 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay | Shigella dysenteriae | 9 | cell-based format | Scientific Literature | ||
10. | ALA3863941 | F | Selectivity index, ratio of CC50 for cytotoxicity against African green monkey Vero cells to IC50 for nhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity | 6 | cell-based format | Scientific Literature | |||
11. | ALA3863945 | F | Inhibition of Shigella dysenteriae Shiga toxin-induced mortality in Balb/c mouse exposed to 5 x LD50 Shigella toxin assessed as reduction in symptomatic effects of toxin at 2 mM, ip preincubated with Stx for 1 hr measured after 0 to 14 days | Mus musculus | 6 | organism-based format | Scientific Literature | ||
12. | ALA3863946 | F | Inhibition of Shigella dysenteriae Shiga toxin-induced mortality in Balb/c mouse exposed to 5 x LD50 Shigella toxin assessed as increase in mouse survival at 2 mM, ip dosed 1 hr before toxin injection measured after 24 to 48 hrs | Mus musculus | 6 | organism-based format | Scientific Literature | ||
13. | ALA3863947 | F | Inhibition of Shigella dysenteriae Shiga toxin-induced mortality in Balb/c mouse exposed to 5 x LD50 Shigella toxin assessed as increase in mouse survival at 2 mM, ip dosed 1 after toxin injection measured after 24 to 48 hrs | Mus musculus | 6 | organism-based format | Scientific Literature | ||
14. | ALA3863948 | T | Toxicity in Balb/c mouse at 2 mM, ip measured after 0 to 14 days | Mus musculus | 6 | organism-based format | Scientific Literature |