# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3867647 | Binding | Displacement of [3H]prazosin from human alpha1A-adrenoceptor expressed in CHO cell membranes measured after 30 mins | Homo sapiens | 11 | ALA3867431 | cell-based format | Scientific Literature | |
2. | ALA3867648 | ADME | Displacement of [3H]prazosin from human alpha1B-adrenoceptor expressed in CHO cell membranes measured after 30 mins | Homo sapiens | 11 | ALA3867431 | cell-based format | Scientific Literature | |
3. | ALA3867649 | Binding | Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins | Homo sapiens | 11 | ALA3867431 | cell-based format | Scientific Literature | |
4. | ALA3867650 | Binding | Antagonist activity at alpha1A-adrenoceptor in Wistar rat prostatic vas deference assessed as inhibition of (-)-NE-induced contractions preincubated for 60 mins before (-)-NE challenge measured after 45 mins | Rattus norvegicus | 10 | ALA3867431 | single protein format | Scientific Literature | |
5. | ALA3867651 | ADME | Antagonist activity at alpha1B-adrenoceptor in Wistar rat spleen assessed as inhibition of phenylphrine-induced contractions measured after 30 mins in presence of (+/-)-propranolol hydrochloride | Rattus norvegicus | 10 | ALA3867431 | single protein format | Scientific Literature | |
6. | ALA3867652 | Binding | Antagonist activity at alpha1D-adrenoceptor in Wistar rat thoracic aorta assessed as inhibition of (-)-NE-induced contractions preincubated for 60 mins before (-)-NE challenge measured after 1 hr in presence of normetanephrine hydrochloride and (+/-)-propranolol hydrochloride | Rattus norvegicus | 10 | ALA3867431 | single protein format | Scientific Literature | |
7. | ALA3867653 | Binding | Competitive antagonist activity at alpha1A-adrenoceptor in Wistar rat prostatic vas deference assessed as inhibition of (-)-NE-induced contractions preincubated for 60 mins before (-)-NE challenge measured after 45 mins by Schild plot analysis | Rattus norvegicus | 1 | ALA3867431 | single protein format | Scientific Literature | |
8. | ALA3867654 | Functional | Antiproliferative activity against human PC3 cells assessed as reduction in cell viability at 0.01 to 10 uM measured after 24 to 72 hrs by MTS assay | Homo sapiens | 1 | ALA3867431 | cell-based format | Scientific Literature |