# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3858844 | B | Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting method | Homo sapiens | 21 | ALA3856249 | cell-based format | Scientific Literature | |
2. | ALA3858845 | B | Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting method relative to control | Homo sapiens | 21 | ALA3856249 | cell-based format | Scientific Literature | |
3. | ALA3858846 | P | Kinetic solubility of the compound in 20% HP-beta-cyclodextrin at pH 4 by UPLC/UV method | 20 | ALA3856249 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3858847 | P | Kinetic solubility of the compound at pH 7 by UPLC/UV method | 20 | ALA3856249 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA3858848 | A | Metabolic stability in human liver microsomes assessed as compound metabolized at 5 uM measured after 15 mins | Homo sapiens | 20 | ALA3856249 | tissue-based format | Scientific Literature | |
6. | ALA3858849 | A | Metabolic stability in rat liver microsomes assessed as compound metabolized at 5 uM measured after 15 mins | Rattus norvegicus | 20 | ALA3856249 | tissue-based format | Scientific Literature | |
7. | ALA3858850 | B | Inhibition of human ERG expressed in HEK293 cells assessed as reduction in maximal tail current at 3 uM and holding potential of -60 mV measured after 5 mins by patch-clamp assay | Homo sapiens | 20 | ALA3856249 | cell-based format | Scientific Literature | |
8. | ALA5149428 | P | Octanol/PBS partition coefficient, logD of compound at pH 7.4 by HPLC analysis | 7 | ALA5143735 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA5149429 | F | Positive allosteric modulation of mGlu2 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells in presence of L-glutamate by luciferase based GloSensor cAMP Assay | Homo sapiens | 7 | ALA5143735 | cell-based format | Scientific Literature | |
10. | ALA5149430 | F | Agonist activity at mGlu2 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP Assay | Homo sapiens | 7 | ALA5143735 | cell-based format | Scientific Literature | |
11. | ALA5149431 | F | Agonist activity at mGlu3 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP Assay | Homo sapiens | 7 | ALA5143735 | cell-based format | Scientific Literature | |
12. | ALA5149432 | F | Agonist activity at mGlu1 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP Assay | Homo sapiens | 7 | ALA5143735 | cell-based format | Scientific Literature | |
13. | ALA5149433 | F | Agonist activity at mGlu4 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP Assay | Homo sapiens | 7 | ALA5143735 | cell-based format | Scientific Literature | |
14. | ALA5149434 | F | Agonist activity at mGlu5 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP Assay | Homo sapiens | 7 | ALA5143735 | cell-based format | Scientific Literature | |
15. | ALA5149435 | F | Agonist activity at mGlu6 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP Assay | Homo sapiens | 7 | ALA5143735 | cell-based format | Scientific Literature | |
16. | ALA5149436 | F | Agonist activity at mGlu8 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP Assay | Homo sapiens | 7 | ALA5143735 | cell-based format | Scientific Literature |