#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA3854930	B	Inhibition of human COT (66 to 395 residues) expressed in Sf21 cells using 5-Fluo-Ahx-AGAGSGQLIDSNleANSFVGTR-NH2 as substrate after 60 mins by caliper microfluidic mobility shift assay	Homo sapiens	25		cell-based format	Scientific Literature
2.	ALA3854933	B	Inhibition of COT in LPS-stimulated human PBMC assessed as reduction in ERK1/2 phosphorylation incubated for 60 mins followed by LPS stimulation for 12 mins by flow cytometric analysis	Homo sapiens	8		single protein format	Scientific Literature
3.	ALA3854934	B	Inhibition of COT in LPS-stimulated human PBMC assessed as reduction in TNFalpha release incubated for 1 hr followed by stimulation with LPS for 4 hrs by HTRF assay	Homo sapiens	8		single protein format	Scientific Literature
4.	ALA3854938	P	Octanol-water partition coefficient, log P of the compound by shake-flask method		11		small-molecule physicochemical format	Scientific Literature
5.	ALA3854940	B	Inhibition of COT in LPS-stimulated human whole blood assessed as reduction in TNFalpha release incubated for 30 mins followed by stimulation with LPS for 3 hrs by HTRF assay	Homo sapiens	7		tissue-based format	Scientific Literature
6.	ALA3854941	P	Equilibrium solubility of the compound at pH 6.8 after 16 hrs by mass spectrometric analysis		9		small-molecule physicochemical format	Scientific Literature
7.	ALA3854942	P	Equilibrium solubility of the compound at pH 4 after 16 hrs by mass spectrometric analysis		9		small-molecule physicochemical format	Scientific Literature
8.	ALA3854943	A	Protein binding in human plasma at 5 uM after 4 hrs by rapid equilibrium dialysis method	Homo sapiens	6		cell-free format	Scientific Literature
9.	ALA3854944	A	Half life in wild type Sprague-Dawley rat liver microsomes at 5 uM preincubated for 3 mins followed by NADPH addition measured after 1 hr by HPLC/MS analysis	Rattus norvegicus	3		tissue-based format	Scientific Literature
10.	ALA3854945	A	Half life in wild type Sprague-Dawley rat liver S9 fraction at 1 uM in presence of NADPH by HPLC/MS analysis	Rattus norvegicus	1		subcellular format	Scientific Literature
11.	ALA3854946	A	Clearance in wild type Sprague-Dawley rat at 1 mg/kg, iv or 3 mg/kg, po	Rattus norvegicus	1		organism-based format	Scientific Literature
12.	ALA3854947	A	Clearance in beagle dog at 0.1 mg/kg, iv or 0.3 mg/kg, po fasted 12 hrs prior to compound administration via cassette dosing and fed 2 hrs post dose	Canis lupus familiaris	1		organism-based format	Scientific Literature
13.	ALA3854948	A	Terminal elimination half life in wild type Sprague-Dawley rat at 1 mg/kg, iv or 3 mg/kg, po	Rattus norvegicus	1		organism-based format	Scientific Literature
14.	ALA3854949	A	Terminal elimination half life in beagle dog at 0.1 mg/kg, iv or 0.3 mg/kg, po fasted 12 hrs prior to compound administration via cassette dosing and fed 2 hrs post dose	Canis lupus familiaris	1		organism-based format	Scientific Literature
15.	ALA3854950	A	Mean residence time in wild type Sprague-Dawley rat at 1 mg/kg, iv or 3 mg/kg, po	Rattus norvegicus	1		organism-based format	Scientific Literature
16.	ALA3854951	A	Mean residence time in beagle dog at 0.1 mg/kg, iv or 0.3 mg/kg, po fasted 12 hrs prior to compound administration via cassette dosing and fed 2 hrs post dose	Canis lupus familiaris	1		organism-based format	Scientific Literature
17.	ALA3854952	A	Dose normalized AUC in wild type Sprague-Dawley rat at 1 mg/kg, iv	Rattus norvegicus	1		organism-based format	Scientific Literature
18.	ALA3854953	A	Dose normalized AUC in beagle dog at 0.1 mg/kg, iv fasted 12 hrs prior to compound administration via cassette dosing and fed 2 hrs post dose	Canis lupus familiaris	1		organism-based format	Scientific Literature
19.	ALA3854954	A	Dose normalized AUC in wild type Sprague-Dawley rat at 3 mg/kg, po	Rattus norvegicus	1		organism-based format	Scientific Literature
20.	ALA3854955	A	Dose normalized AUC in beagle dog at 0.3 mg/kg, po fasted 12 hrs prior to compound administration via cassette dosing and fed 2 hrs post dose	Canis lupus familiaris	1		organism-based format	Scientific Literature