# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3880148 | B | Inhibition of A-Raf (unknown origin) assessed as decrease in biotin-tagged MEK1 phosphorylation after 45 mins | Homo sapiens | 34 | single protein format | Patent Bioactivity Data | ||
2. | ALA3880149 | B | Inhibition of B-Raf (unknown origin) assessed as decrease in biotin-tagged MEK1 phosphorylation after 45 mins | Homo sapiens | 90 | single protein format | Patent Bioactivity Data | ||
3. | ALA3880150 | B | Inhibition of B-Raf V600E mutant (unknown origin) assessed as decrease in biotin-tagged MEK1 phosphorylation after 45 mins | Homo sapiens | 91 | single protein format | Patent Bioactivity Data | ||
4. | ALA3880153 | F | Cytotoxicity against human A375 cells expressing B-RAF V600E mutant assessed as growth inhibition after 3 days by ATPlite 1 step luminescence assay | Homo sapiens | 90 | cell-based format | Patent Bioactivity Data | ||
5. | ALA3880154 | F | Cytotoxicity against human COLO205 cells expressing B-RAF V600E mutant assessed as growth inhibition after 3 days by ATPlite 1 step luminescence assay | Homo sapiens | 74 | cell-based format | Patent Bioactivity Data | ||
6. | ALA3880158 | F | Cytotoxicity against human SK-MEL-2 cells expressing Ras mutant assessed as growth inhibition at 10 uM after 3 days by ATPlite 1 step luminescence assay | Homo sapiens | 41 | cell-based format | Patent Bioactivity Data | ||
7. | ALA3880159 | F | Cytotoxicity against human SW620 cells expressing Ras mutant assessed as growth inhibition at 10 uM after 3 days by ATPlite 1 step luminescence assay | Homo sapiens | 62 | cell-based format | Patent Bioactivity Data | ||
8. | ALA3880160 | F | Antitumor activity against human COLO205 cells xenografted in nu/nu mouse assessed as tumor growth inhibition at 10 mg/kg administered for 14 days measured twice a week during compound dosing relative to control | Homo sapiens | 15 | organism-based format | Patent Bioactivity Data | ||
9. | ALA3880161 | A | Aqueous solubility of the compound in simulated gastric fluid at pH 1.5 | 65 | tissue-based format | Patent Bioactivity Data | |||
10. | ALA3880162 | A | Aqueous solubility of the compound in simulated intestinal fluid at pH 4.5 | 65 | assay format | Patent Bioactivity Data | |||
11. | ALA3880163 | A | Aqueous solubility of the compound in simulated intestinal fluid at pH 6.8 | 65 | assay format | Patent Bioactivity Data | |||
12. | ALA3880164 | P | Aqueous solubility of the compound in hepes buffer at pH 7.4 | 65 | small-molecule physicochemical format | Patent Bioactivity Data | |||
13. | ALA3880165 | A | Inhibition of CYP1A2 (unknown origin) using CEC as substrate after 15 mins | Homo sapiens | 85 | single protein format | Patent Bioactivity Data | ||
14. | ALA3880166 | A | Inhibition of CYP2C19 (unknown origin) using CEC as substrate after 30 mins | Homo sapiens | 84 | single protein format | Patent Bioactivity Data | ||
15. | ALA3880167 | A | Inhibition of CYP2C9 (unknown origin) using MFC as substrate after 45 mins | Homo sapiens | 85 | single protein format | Patent Bioactivity Data | ||
16. | ALA3880168 | A | Inhibition of CYP2D6 (unknown origin) using AMMC as substrate after 30 mins | Homo sapiens | 85 | single protein format | Patent Bioactivity Data | ||
17. | ALA3880169 | A | Inhibition of CYP3A4 (unknown origin) using BFC as substrate after 30 mins | Homo sapiens | 85 | single protein format | Patent Bioactivity Data | ||
18. | ALA3880170 | A | Inhibition of CYP3A4 (unknown origin) using BQ as substrate after 30 mins | Homo sapiens | 85 | single protein format | Patent Bioactivity Data |