# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3878920 | B | Partial agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 at holding potential of -90 mV by whole-cell voltage clamp technique | Rattus norvegicus | 6 | ALA3877302 | cell-based format | Scientific Literature | |
2. | ALA3878921 | B | Intrinsic activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under the current curve at holding potential of -90 mV at 10 uM by whole-cell voltage clamp technique relative to acetylcholine | Rattus norvegicus | 6 | ALA3877302 | cell-based format | Scientific Literature | |
3. | ALA3878922 | B | Intrinsic activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as induction of peak current at holding potential of -90 mV at 10 uM by whole-cell voltage clamp technique relative to acetylcholine | Rattus norvegicus | 6 | ALA3877302 | cell-based format | Scientific Literature | |
4. | ALA3878925 | B | Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 measured for 2 mins by FLIPR assay | Rattus norvegicus | 34 | ALA3877302 | cell-based format | Scientific Literature | |
5. | ALA3878926 | A | Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins followed by addition of acetylcholine measured for 2 mins by Fluo-4AM dye based FLIPR assay | Homo sapiens | 34 | ALA3877302 | cell-based format | Scientific Literature | |
6. | ALA3878927 | A | Selectivity ratio of IC50 for human 5-HT3A expressed in HEK293 cells to EC50 for rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 | 33 | ALA3877302 | cell-based format | Scientific Literature | ||
7. | ALA3878928 | A | Selectivity ratio of IC50 for human 5-HT3A expressed in HEK293 cells to EC50 for rat alpha1beta1deltaepsilon nAChR expressed in HEK293 cells | 1 | ALA3877302 | cell-based format | Scientific Literature | ||
8. | ALA3878929 | A | Selectivity ratio of IC50 for human 5-HT3A expressed in HEK293 cells to EC50 for rat alpha3beta4 nAChR expressed in HEK293 cells | 1 | ALA3877302 | cell-based format | Scientific Literature | ||
9. | ALA3878930 | A | Selectivity ratio of IC50 for human 5-HT3A expressed in HEK293 cells to EC50 for rat alpha4beta2 nAChR expressed in HEK293 cells | 1 | ALA3877302 | cell-based format | Scientific Literature | ||
10. | ALA3878931 | A | Metabolic stability in human microsomes assessed as compound remaining measured after 10 mins | Homo sapiens | 2 | ALA3877302 | assay format | Scientific Literature | |
11. | ALA3878932 | A | Metabolic stability in mouse microsomes assessed as compound remaining measured after 10 mins | Mus musculus | 2 | ALA3877302 | assay format | Scientific Literature | |
12. | ALA3878933 | A | Metabolic stability in rat microsomes assessed as compound remaining measured after 10 mins | Rattus norvegicus | 2 | ALA3877302 | assay format | Scientific Literature | |
13. | ALA3878934 | B | Displacement of [125I]Tyr54-alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes co-expressing human RIC3 measured after 2 hrs by gamma counting method | Rattus norvegicus | 2 | ALA3877302 | cell-based format | Scientific Literature | |
14. | ALA3878935 | B | Agonist activity at rat alpha1beta1deltaepsilon nAChR expressed in HEK293 cells for 2 mins by FLIPR assay | Rattus norvegicus | 2 | ALA3877302 | cell-based format | Scientific Literature | |
15. | ALA3878936 | B | Agonist activity at rat alpha3beta4 nAChR expressed in HEK293 cells for 2 mins by FLIPR assay | Rattus norvegicus | 2 | ALA3877302 | cell-based format | Scientific Literature | |
16. | ALA3878937 | B | Agonist activity at rat alpha4beta2 nAChR expressed in HEK293 cells for 2 mins by FLIPR assay | Rattus norvegicus | 2 | ALA3877302 | cell-based format | Scientific Literature | |
17. | ALA3878938 | A | Clearance in rat | Rattus norvegicus | 1 | ALA3877302 | assay format | Scientific Literature | |
18. | ALA3878939 | A | Oral bioavailability in rat at 10 mg/kg | Rattus norvegicus | 1 | ALA3877302 | organism-based format | Scientific Literature | |
19. | ALA3878940 | A | Plasma concentration in Wistar rat at 10 mg/kg, sc measured after 30 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3877302 | organism-based format | Scientific Literature | |
20. | ALA3878941 | A | Drug uptake in Wistar rat brain at 10 mg/kg, sc measured after 30 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3877302 | organism-based format | Scientific Literature |