| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3869540 | A | Unbound fraction in mouse | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA3869541 | A | AUC (0 to 24 hrs) in rat at 10 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA3869542 | A | Cmax in rat at 10 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA3869543 | A | Half life in rat at 10 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA3869544 | A | Ratio of drug level in brain to plasma in mouse at 10 mg/kg, ip after 30 mins | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA3869545 | A | Tmax in rat at 10 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA3869546 | F | Antagonist activity at recombinant human mGlu1 receptor expressed in hamster AV12 cells coexpressing human EAAT1/Galpha1s assessed as inhibition of Ca2+ flux by Fluo-3-AM dye based FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA3869547 | B | Activity at ionotropic glutamate receptor 1 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA3869548 | F | Antidepressant activity in rat assessed as increase in REM sleep at 3 to 10 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA3869549 | B | Displacement of [3H]-LY459477 from human mGlu2 receptor expressed in hamster AV12 cell membranes co-expressing human EAAT1 after 90 mins by liquid scintillation counting method | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA3869550 | F | Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhibited forskolin-stimulated cAMP formation after 20 mins by HTRF assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 12. | ALA3869551 | F | Antagonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhibited forskolin-stimulated cAMP formation after 20 mins by HTRF assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 13. | ALA3869552 | F | Antagonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells assessed as inhibition of DCG-4-inhibited forskolin-stimulated cAMP formation up to 25 uM after 20 min by HTRF assay relative to control | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 14. | ALA3869553 | F | Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells assessed as inhibition of DCG-4-inhibited forskolin-stimulated cAMP formation up to 25 uM after 20 mins by HTRF assay relative to control | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 15. | ALA3869554 | F | Agonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as increase in forskolin-stimulated cAMP formation up to 25 uM after 20 mins by HTRF assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 16. | ALA3869555 | F | Agonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as increase in forskolin-stimulated cAMP formation up to 25 uM after 20 mins by HTRF assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 17. | ALA3869556 | F | Agonist activity at recombinant human mGlu1 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as increase in Ca2+ flux by Fluo-3-AM dye based FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA3869557 | F | Antagonist activity at recombinant human mGlu4 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as inhibition of Ca2+ flux by Fluo-3-AM dye based FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA3869558 | F | Agonist activity at recombinant human mGlu4 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as increase in Ca2+ flux by Fluo-3-AM dye based FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA3869559 | F | Antagonist activity at recombinant human mGlu5 receptor expressed in hamster AV12 cells coexpressing human EAAT1/Galpha1s assessed as inhibition of Ca2+ flux by Fluo-3-AM dye based FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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