| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3878759 | B | Inhibition of TSPO in mouse HT22 cells assessed as protection against amyloid beta (1 to 42)-induced mitochondrial membrane potential loss by measuring recovery of mitochondrial membrane potential at 5 uM preincubated for 10 mins followed by amyloid beta (1 to 42) addition measured every 1 hr for 3 hrs by JC1 staining based fluorescence assay relative to control | Mus musculus | 59 | cell-based format | Scientific Literature | ||
| 2. | ALA3878760 | B | Inhibition of TSPO in mouse HT22 cells assessed as protection against amyloid beta (1 to 42)-induced mitochondrial membrane potential loss by measuring recovery of ATP production at 5 uM preincubated for 10 mins followed by amyloid beta (1 to 42) addition measured after 7 hrs by luciferase reporter gene assay relative to control | Mus musculus | 25 | cell-based format | Scientific Literature | ||
| 3. | ALA3878761 | T | Cytotoxicity against mouse HT22 cells assessed as cell viability at 5 uM after 24 hrs by MTT assay relative to control | Mus musculus | 22 | organism-based format | Scientific Literature | ||
| 4. | ALA3878762 | B | Inhibition of TSPO in mouse HT22 cells assessed as inhibition of amyloid beta (1 to 42)-induced toxicity at 5 uM after 24 hrs by MTT assay relative to control | Mus musculus | 10 | cell-based format | Scientific Literature | ||
| 5. | ALA3878763 | B | Inhibition of TSPO in mouse HT22 cells assessed as inhibition of amyloid beta (1 to 42)-induced ROS generation at 5 uM after 6 hrs by DCFDA staining based fluorescence assay relative to control | Mus musculus | 10 | cell-based format | Scientific Literature | ||
| 6. | ALA3878764 | A | Inhibition of recombinant human CYP1A2 expressed in baculosomes coexpressing rabbit NADPH-P450 reudctase assessed as residual activity at 10 uM preincubated for 5 mins followed by substrate and NADP+ addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 7. | ALA3878765 | A | Inhibition of recombinant human CYP2D6 expressed in baculosomes coexpressing rabbit NADPH-P450 reudctase assessed as residual activity at 10 uM preincubated for 5 mins followed by substrate and NADP+ addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 8. | ALA3878766 | A | Inhibition of recombinant human CYP2C9 expressed in baculosomes coexpressing rabbit NADPH-P450 reudctase assessed as residual activity at 10 uM preincubated for 5 mins followed by substrate and NADP+ addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 9. | ALA3878767 | A | Inhibition of recombinant human CYP3A4 expressed in baculosomes coexpressing rabbit NADPH-P450 reudctase assessed as residual activity at 10 uM preincubated for 5 mins followed by substrate and NADP+ addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 10. | ALA3878768 | A | Inhibition of recombinant human CYP2C19 expressed in baculosomes coexpressing rabbit NADPH-P450 reudctase assessed as residual activity at 10 uM preincubated for 5 mins followed by substrate and NADP+ addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 11. | ALA3878769 | B | Inhibition of human ERG expressed in CHOK1 cells by automated patch clamp method | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 12. | ALA3878770 | F | Cognition enhancing effect in ICR mouse model of acute Alzheimer's disease assessed as reversal of amyloid beta (1 to 42)-induced cognitive deficit by measuring spatial working memory at 30 mg/kg, ip daily for 6 days measured on day 7 by Y maze spontaneous alteration test relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA3878771 | F | Reversal of coginitive deficit in double APP/PS1 transgenic Alzheimer's disease mouse model assessed as increase in freezing response at 30 mg/kg, po daily for 1 month by contextual fear conditioning test | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 14. | ALA3878772 | A | Auc (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3878773 | A | AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3878774 | A | AUClast in Sprague-Dawley rat at 10 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3878775 | A | AUClast in Sprague-Dawley rat at 10 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3878776 | A | Terminal half life in Sprague-Dawley rat at 10 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3878777 | A | Terminal half life in Sprague-Dawley rat at 10 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3878778 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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