# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3880448 | B | Inhibition of pig brain TRH-DE at 1 mM using Glp-His-ProAMC as substrate by DPP-4-based continuous fluorometric method | Sus scrofa | 10 | ALA3880382 | assay format | Patent Bioactivity Data | |
2. | ALA3880449 | B | Inhibition of pig brain TRH-DE using Glp-His-ProAMC as substrate by DPP-4-based continuous fluorometric method | Sus scrofa | 21 | ALA3880382 | assay format | Patent Bioactivity Data | |
3. | ALA3880451 | B | Substrate activity at pig brain TRH-DE assessed as rate of hydrolysis at 1 mM incubated for 18 hrs by HPLC analysis | Sus scrofa | 26 | ALA3880382 | assay format | Patent Bioactivity Data | |
4. | ALA3880454 | F | In vivo inhibition of TRH-DE in cannulated Wistar rat assessed as TRH-mediated increase in locomotion at 10 mg/kg, ip measured every 5 mins for 30 secs during 40 mins of observation period | Rattus norvegicus | 1 | ALA3880382 | organism-based format | Patent Bioactivity Data | |
5. | ALA3880464 | B | Displacement of [3H]-3MeHis-TRH from TRH receptor in Sprague-Dawley rat cortical membranes | Rattus norvegicus | 3 | ALA3880382 | assay format | Patent Bioactivity Data | |
6. | ALA3880468 | B | Reversible inhibition of pig brain TRH-DE using Glp-His-ProAMC as substrate at 160 uM preincubated for 75 mins by by DPP-4-based continuous fluorometric method | Sus scrofa | 1 | ALA3880382 | assay format | Patent Bioactivity Data | |
7. | ALA3880471 | B | Time-dependent inhibition of pig brain TRH-DE using Glp-His-ProAMC as substrate at 160 uM preincubated for 75 mins by DPP-4-based continuous fluorometric method | Sus scrofa | 1 | ALA3880382 | assay format | Patent Bioactivity Data | |
8. | ALA3880474 | B | Competitive inhibition of pig brain TRH-DE at 12.5 to 50 uM using Glp-His-ProAMC as substrate by Lineweaver-Burk analysis | Sus scrofa | 1 | ALA3880382 | assay format | Patent Bioactivity Data | |
9. | ALA3880475 | F | In vivo inhibition of TRH-DE in cannulated Wistar rat assessed as increase in TRH-mediated locomotion at 5 ug in 1 ul, icv after 30 mins | Rattus norvegicus | 1 | ALA3880382 | organism-based format | Patent Bioactivity Data |