#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA3868323	A	Intrinsic clearance in dog liver microsomes	Canis lupus familiaris	2		tissue-based format	Scientific Literature
2.	ALA3868324	F	Antagonist activity at rat OX2 receptor assessed as inhibition of Ala-6,12 orexin-A-induced calcium increase preincubated for 5 mins prior to Ala-6,12 orexin-A addition measured at 1 sec intervals for 1 min by Fluo-4AM dye-based FLIPR assay	Rattus norvegicus	3		single protein format	Scientific Literature
3.	ALA3868325	A	Intrinsic clearance in rat liver microsomes	Rattus norvegicus	5		tissue-based format	Scientific Literature
4.	ALA3868327	B	Substrate activity at rat P-gp assessed as ratio of apparent permeability from basolateral to apical side over apical to basolateral side	Rattus norvegicus	9		assay format	Scientific Literature
5.	ALA3868330	A	Intrinsic clearance in human liver microsomes	Homo sapiens	2		tissue-based format	Scientific Literature
6.	ALA3868331	B	Selectivity index, ratio of IC50 for human OX1 receptor to IC50 for rat OX1 receptor		2		assay format	Scientific Literature
7.	ALA3868332	A	Oral bioavailability in rat at 10 mg/kg	Rattus norvegicus	4		organism-based format	Scientific Literature
8.	ALA3868333	A	Clearance in rat at 2 mg/kg, iv	Rattus norvegicus	5		organism-based format	Scientific Literature
9.	ALA3868336	A	Protein binding in dog plasma	Canis lupus familiaris	3		cell-free format	Scientific Literature
10.	ALA3868337	F	Antagonist activity at rat OX1 receptor assessed as inhibition of Ala-6,12 orexin-A-induced calcium increase preincubated for 5 mins prior to Ala-6,12 orexin-A addition measured at 1 sec intervals for 1 min by Fluo-4AM dye-based FLIPR assay	Rattus norvegicus	3		single protein format	Scientific Literature
11.	ALA3868338	B	Displacement of (2S)-N-(2-phenylphenyl)-1-[2-[1-(tritritiomethyl)benzimidazol-2-yl]sulfanylacetyl]pyrrolidine-2-carboxamide from human OX1 receptor Ile408-Val mutant expressed on CHO cell membrane measured after 3 hrs by TopCount method	Homo sapiens	48		cell-based format	Scientific Literature
12.	ALA3868339	B	Displacement of (2S)-N-(2-pyrrol-1-ylphenyl)-1-[2-[1-(tritritiomethyl)benzimidazol-2-yl]sulfanylacetyl]pyrrolidine-2-carboxamide from human OX2 receptor expressed on CHO cell membrane measured after 3 hrs by TopCount method	Homo sapiens	48		cell-based format	Scientific Literature
13.	ALA3868340	B	Selectivity index, ratio of Ki for human OX2 receptor expressed on CHO cell membrane to Ki for Ile408-Val variant human OX1 receptor expressed on CHO cell membrane	Homo sapiens	46		cell-based format	Scientific Literature
14.	ALA3868341	B	Antagonist activity at human OX1 receptor Ile408-Val mutant expressed on CHO cell membrane assessed as inhibition of Ala-6,12 orexin-A-induced calcium increase preincubated for 5 mins prior to Ala-6,12 orexin-A addition measured at 1 sec intervals for 1 min by Fluo-4AM dye-based FLIPR assay	Homo sapiens	3		cell-based format	Scientific Literature
15.	ALA3868342	F	Antagonist activity at human OX2 receptor expressed on CHO cell membrane assessed as inhibition of Ala-6,12 orexin-A-induced calcium increase preincubated for 5 mins prior to Ala-6,12 orexin-A addition measured at 1 sec intervals for 1 min by Fluo-4AM dye-based FLIPR assay	Homo sapiens	3		cell-based format	Scientific Literature
16.	ALA3868344	B	Selectivity index, ratio of IC50 for rat OX2 receptor to IC50 for rat OX1 receptor	Rattus norvegicus	3		assay format	Scientific Literature
17.	ALA3868345	P	Aqueous solubility of the compound at pH 2		5		small-molecule physicochemical format	Scientific Literature
18.	ALA3868346	P	Aqueous solubility of the compound at pH 7		6		small-molecule physicochemical format	Scientific Literature
19.	ALA3868347	A	Protein binding in human plasma	Homo sapiens	3		cell-free format	Scientific Literature
20.	ALA3868348	A	Intrinsic clearance in rhesus monkey liver microsomes	Macaca mulatta	2		tissue-based format	Scientific Literature