# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3874973 | B | Inhibition of human erythrocyte carbonic anhydrase 1 preincubated for 15 mins prior to testing by bromothymol blue-based stopped-flow CO2 hydration assay | Homo sapiens | 22 | single protein format | Scientific Literature | ||
2. | ALA3874974 | B | Inhibition of human erythrocyte carbonic anhydrase 2 preincubated for 15 mins prior to testing by bromothymol blue-based stopped-flow CO2 hydration assay | Homo sapiens | 22 | single protein format | Scientific Literature | ||
3. | ALA3874975 | B | Inhibition of Malassezia globosa beta-carbonic anhydrase preincubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay | Malassezia globosa | 22 | assay format | Scientific Literature | ||
4. | ALA4268729 | B | Inhibition of Escherichia coli NDM4 assessed as potentiation of meropenem-induced antibacterial activity by measuring zone of inhibition at 10 uL after 16 to 18 hrs by disc diffusion method (Rvb = 9.6 +/- 0.5 millimeter) | Escherichia coli | 9 | single protein format | Scientific Literature | ||
5. | ALA4268730 | B | Inhibition of Escherichia coli IMP4 assessed as potentiation of meropenem-induced antibacterial activity by measuring zone of inhibition at 10 uL after 16 to 18 hrs by disc diffusion method (Rvb = 9.8 +/- 0.6 millimeter) | Escherichia coli | 9 | assay format | Scientific Literature | ||
6. | ALA4268731 | B | Inhibition of Escherichia coli NDM1 assessed as potentiation of meropenem-induced antibacterial activity by measuring fold reduction in meropenem MIC at 64 ug/ml after 16 to 18 hrs by broth microdilution method relative to meropenem alone | Escherichia coli | 2 | single protein format | Scientific Literature | ||
7. | ALA4268732 | B | Inhibition of Proteus mirabilis NDM1 assessed as potentiation of meropenem-induced antibacterial activity by measuring fold reduction in meropenem MIC at 64 ug/ml after 16 to 18 hrs by broth microdilution method relative to meropenem alone | Proteus mirabilis | 2 | assay format | Scientific Literature | ||
8. | ALA4268733 | B | Inhibition of Citrobacter freundii NDM1 assessed as potentiation of meropenem-induced antibacterial activity by measuring fold reduction in meropenem MIC at 64 ug/ml after 16 to 18 hrs by broth microdilution method relative to meropenem alone | Citrobacter freundii | 2 | assay format | Scientific Literature | ||
9. | ALA4268734 | B | Inhibition of Klebsiella pneumoniae NDM1 assessed as potentiation of meropenem-induced antibacterial activity by measuring fold reduction in meropenem MIC at 64 ug/ml after 16 to 18 hrs by broth microdilution method relative to meropenem alone | Klebsiella pneumoniae | 2 | single protein format | Scientific Literature | ||
10. | ALA4268735 | B | Inhibition of Escherichia coli IMP4 assessed as potentiation of meropenem-induced bactericidal activity by measuring bacterial count at 4 times MIC incubated for 24 hrs followed by replating on agar plates and further incubated for 16 to 18 hrs measured for 24 hrs by time kill assay | Escherichia coli | 2 | assay format | Scientific Literature | ||
11. | ALA4268736 | B | Inhibition of Escherichia coli NDM1 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 64 ug/ml after 16 to 18 hrs by broth microdilution method (Rvb = 10 to 320 ug/ml) | Escherichia coli | 9 | single protein format | Scientific Literature | ||
12. | ALA4268737 | B | Inhibition of Proteus mirabilis NDM1 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 64 ug/ml after 16 to 18 hrs by broth microdilution method (Rvb = 20 to 160 ug/ml) | Proteus mirabilis | 9 | assay format | Scientific Literature | ||
13. | ALA4268739 | B | Inhibition of Klebsiella pneumoniae NDM1 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 64 ug/ml after 16 to 18 hrs by broth microdilution method (Rvb = 40 to 80 ug/ml) | Klebsiella pneumoniae | 9 | single protein format | Scientific Literature | ||
14. | ALA4268740 | B | Inhibition of Klebsiella pneumoniae IMP4 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 64 ug/ml after 16 to 18 hrs by broth microdilution method (Rvb = 20 to 40 ug/ml) | Klebsiella pneumoniae | 9 | single protein format | Scientific Literature | ||
15. | ALA4268741 | B | Inhibition of Escherichia coli IMP4 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 64 ug/ml after 16 to 18 hrs by broth microdilution method (Rvb = 20 to 160 ug/ml) | Escherichia coli | 9 | assay format | Scientific Literature | ||
16. | ALA4268743 | B | Inhibition of Escherichia coli IMP4 assessed as potentiation of meropenem-induced bactericidal activity by measuring reduction in bacterial colonies at 8 times MIC incubated up to 8 hrs followed by replating on agar plates and further incubated for 16 to 18 hrs measured for 24 hrs by time kill assay | Escherichia coli | 1 | assay format | Scientific Literature | ||
17. | ALA4268747 | B | Inhibition of Escherichia coli NDM1 assessed as potentiation of meropenem-induced bactericidal activity by measuring meropenem MBC after 20 to 24 hrs in presence of 50% serum | Escherichia coli | 1 | single protein format | Scientific Literature | ||
18. | ALA4268748 | B | Inhibition of Escherichia coli NDM1 assessed as potentiation of meropenem-induced bactericidal activity by measuring meropenem MBC after 20 to 24 hrs in presence of 50% blood | Escherichia coli | 1 | single protein format | Scientific Literature | ||
19. | ALA4268749 | A | Hemolytic activity against sheep RBC at 1.953 to 1000 ug/ml after 1 hr | Ovis aries | 3 | cell-based format | Scientific Literature | ||
20. | ALA4268750 | A | Cytotoxicity against human HeLa cells after 24 hrs by CCK8 assay | Homo sapiens | 3 | cell-based format | Scientific Literature |