| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3862673 | B | Inhibition of JNK phosphorylation in peptidoglycan-stimulated mouse RAW264.7 cells at 6 uM pretreated for 30 mins followed by peptidoglycan stimulation for 15 mins by Western blot method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA3862674 | B | Inhibition of ERK1/2 phosphorylation in peptidoglycan-stimulated mouse RAW264.7 cells at 6 uM pretreated for 30 mins followed by peptidoglycan stimulation for 15 mins by Western blot method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA3862675 | F | Antiinflammatory activity in specific pathogen-free C57BL/6 mouse assessed as inhibition of carrageenan-induced neutrophil migration into peritoneal cavity at 300 ug/kg, administered subcutaneously for 30 mins prior to carrageenan challenge measured after 4 hrs using Neubauer chamber by optical microscopic analysis | Mus musculus | 1 | assay format | Scientific Literature | ||
| 4. | ALA3862676 | F | Anti-inflammatory activity in specific pathogen-free C57BL/6 mouse assessed as inhibition of carrageenan-induced leukocyte rolling into mesenteric venules at 300 ug/kg administered subcutaneously for 30 mins prior to carrageenan challenge measured after 2 hrs for 10 mins by intravital microscopic analysis | Mus musculus | 1 | assay format | Scientific Literature | ||
| 5. | ALA3862677 | F | Antiinflammatory activity in specific pathogen-free C57BL/6 mouse assessed as inhibition of carrageenan-induced leukocyte adhesion in mesenteric venules at 300 ug/kg administered subcutaneously for 30 mins prior to carrageenan challenge measured after 4 hrs by intravital microscopy | Mus musculus | 1 | assay format | Scientific Literature | ||
| 6. | ALA3862678 | F | Anti-inflammatory activity in specific pathogen-free C57BL/6 mouse assessed as reduction in carrageenan-induced TNF-alpha release in peritoneal cavity at 300 ug/kg administered subcutaneously for 30 mins prior to carrageenan challenge measured after 1.5 hrs by ELISA | Mus musculus | 1 | assay format | Scientific Literature | ||
| 7. | ALA3862679 | F | Antiinflammatory activity in specific pathogen-free C57BL/6 mouse assessed as reduction in carrageenan-induced CXCL2/MIP-2 release in peritoneal cavity at 300 ug/kg administered subcutaneously for 30 mins prior to carrageenan challenge measured after 3 hrs by ELISA | Mus musculus | 1 | assay format | Scientific Literature | ||
| 8. | ALA3862680 | F | Antiinflammatory activity in specific pathogen-free C57BL/6 mouse assessed as inhibition of mBSA-induced neutrophil migration into joint cavity at 100 ug/kg, administered post 21 days of immunization subcutaneously for 30 mins prior to mBSA challenge measured after 6 hrs by cell counting method | Mus musculus | 1 | assay format | Scientific Literature | ||
| 9. | ALA3862681 | F | Antiinflammatory activity in specific pathogen-free C57BL/6 mouse assessed as reduction of mBSA-induced TNF-alpha release in joint cavity at 100 ug/kg, administered post 21 days of immunization subcutaneously for 30 mins prior mBSA challenge measured after 1.5 hrs by ELISA | Mus musculus | 1 | assay format | Scientific Literature | ||
| 10. | ALA3862682 | F | Antiinflammatory activity in specific pathogen-free C57BL/6 mouse assessed as reduction in mBSA-induced myeloperoxidase activity in joint cavity at 100 ug/kg administered post 21 days of immunization subcutaneously for 30 mins prior to mBSA challenge measured after 6 hrs by bioluminescence assay | Mus musculus | 1 | assay format | Scientific Literature | ||
| 11. | ALA3862683 | F | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of peptidoglycan-stimulated TNFalpha production at 0.6 to 6 uM pretreated 30 mins prior to peptidoglycan challenge measured after 4 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA3862684 | F | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated TNFalpha production at 0.6 to 6 uM pretreated 30 mins prior to LPS challenge measured after 4 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3862685 | F | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of peptidoglycan-stimulated CXCL2/MIP-2 release at 0.6 to 6 uM pretreated 30 mins prior to peptidoglycan challenge measured after 4 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA3862686 | F | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated CXCL2/MIP-2 release at 0.6 to 6 uM pretreated 30 mins prior to LPS challenge measured after 4 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA3862687 | T | Cytotoxicity against mouse RAW264.7 cells assessed as induction of apoptosis at 6 uM measured after 4 hrs by Annexin V-FTIC/propidium iodide staining-based flow cytometric analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3862688 | T | Cytotoxicity against mouse RAW264.7 cells at 6 uM measured after 4 hrs by MTT assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3862689 | B | Inhibition of MAPK p38 phosphorylation in peptidoglycan-stimulated mouse RAW264.7 cells at 6 uM pretreated for 30 mins followed by peptidoglycan stimulation for 15 mins by Western blot method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA3862690 | B | Inhibition of c-jun phosphorylation in peptidoglycan-stimulated mouse RAW264.7 cells at 6 uM pretreated for 30 mins followed by peptidoglycan stimulation for 30 mins by Western blot method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA3862691 | B | Inhibition of NFkappaB activation (unknown origin) expressed in mouse RAW264.7 cells at 0.6 to 6 uM pretreated for 30 mins followed by peptidoglycan challenge measured after 4 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA3862692 | B | Effect on IKB-alpha degradation in peptidoglycan-stimulated mouse RAW264.7 cells at 6 uM pretreated for 30 mins followed by peptidoglycan stimulation measured after 15 mins by Western blot method | Mus musculus | 1 | cell-based format | Scientific Literature |
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