| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3860331 | B | Potency index, ratio of GSA-10 EC50 to compound EC50 for activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA3860332 | F | Induction of mouse C3H10T1/2 cell differentiation into osteoblast at 1 uM in presence of smo ShRNA incubated for 6 days by alkaline phosphatase assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA3860335 | B | Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast at 0.3 uM in presence of adenylate cyclase activator forskolin incubated for 6 days by alkaline phosphatase assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA3860337 | B | Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast at 0.3 uM in presence of phosphodiesterase inhibitor IBMX incubated for 6 days by alkaline phosphatase assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA3860338 | B | Agonist activity at Smo in mouse NIH/3T3 cells transfected with Gli-dependent firefly luciferase reporter assessed as stimulation of Gli transcription factor incubated for 40 hrs | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA3860340 | B | Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay | Mus musculus | 37 | cell-based format | Scientific Literature | ||
| 7. | ALA3860341 | B | Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast at 10 uM incubated for 6 days by alkaline phosphatase assay relative to GSA-10 | Mus musculus | 36 | cell-based format | Scientific Literature | ||
| 8. | ALA3860344 | B | Activity at Smo in cerebellar granule cell precursors isolated from rat at postnatal day 8 assessed as stimulation of proliferation by [3H]-thymidine incorporation assay | Rattus norvegicus | 3 | single protein format | Scientific Literature | ||
| 9. | ALA3860346 | B | Induction of Smo translocation to primary cilium in mouse NIH/3T3 cells at 10 uM after overnight incubation by DAPI staining-based immunofluorescence assay relative to control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA3860351 | B | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as effect on Gli1 expression at 10 uM after 48 hrs by RT-PCR method relative to vehicle-treated control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA3860352 | B | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as effect on Gli2 expression at 10 uM after 48 hrs by RT-PCR method relative to vehicle-treated control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA3860353 | B | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as effect on Gli3 expression at 10 uM after 48 hrs by RT-PCR method relative to vehicle-treated control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA3860354 | B | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as effect on Ptc1 expression at 10 uM after 48 hrs by RT-PCR method relative to vehicle-treated control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA3860356 | B | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as effect on Smo expression at 10 uM after 48 hrs by RT-PCR method relative to vehicle-treated control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA3860357 | B | Antagonist activity at Smo in mouse NIH/3T3 cells transfected with Gli-dependent firefly luciferase reporter assessed as inhibition of SAG-induced maximal stimulation of Gli transcription factor at 1 uM incubated for 40 hrs relative to control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA3860358 | B | Induction of Renilla reniformis luciferase activity at 10 uM relative to control | Renilla reniformis | 4 | single protein format | Scientific Literature | ||
| 17. | ALA3860359 | B | Antagonist activity at Smo in mouse NIH/3T3 cells transfected with Gli-dependent firefly luciferase reporter assessed as reduction of SAG EC50 for stimulation of Gli transcription factor at 1 uM incubated for 40 hrs | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA3860360 | B | Activation of Wnt signaling pathway in HEK293 cells at 10 uM incubated for 40 hrs by TCF/LEF luciferase reporter gene assay | Homo sapiens | 3 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!