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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA3888194 B Nav1.7 In Vitro PX Assay: HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system (Molecular Devices, LLC, Sunnyvale, Calif.). Compound effects were measured on a partially inactivated state of the sodium channel. Cells were clamped to a holding potential yielding 20 to 50% inactivation. To elicit sodium current, channels were activated by pulsing to -10 mV for 20 msec. This voltage protocol was repeated at a rate of 0.1 Hz throughout the experiment. A single concentration of test compound was applied to cells for a duration of 3 minutes. 641 ALA3886193 cell-based format BindingDB Database 2. ALA4012328 B Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress electrophysiology assay Homo sapiens 32 ALA4011607 cell-based format Scientific Literature 3. ALA4012329 A Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by patchXpress electrophysiology assay Homo sapiens 4 ALA4011607 cell-based format Scientific Literature 4. ALA4012330 A Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPH Homo sapiens 29 ALA4011607 assay format Scientific Literature 5. ALA4012331 A Clearance in rat at 0.5 mg/kg, iv Rattus norvegicus 6 ALA4011607 organism-based format Scientific Literature 6. ALA4012332 A Unbound clearance in rat at 0.5 mg/kg, iv Rattus norvegicus 6 ALA4011607 organism-based format Scientific Literature 7. ALA4012333 A Clearance in dog at 0.25 mg/kg, iv Canis lupus familiaris 5 ALA4011607 organism-based format Scientific Literature 8. ALA4012334 A Unbound clearance in dog at 0.25 mg/kg, iv Canis lupus familiaris 5 ALA4011607 organism-based format Scientific Literature 9. ALA4012335 A Volume of distribution at steady state in rat at 0.5 mg/kg, iv Rattus norvegicus 5 ALA4011607 organism-based format Scientific Literature 10. ALA4012336 A Volume of distribution at steady state in dog at 0.25 mg/kg, iv Canis lupus familiaris 5 ALA4011607 organism-based format Scientific Literature 11. ALA4012337 A Half life in rat at 0.5 mg/kg, iv Rattus norvegicus 5 ALA4011607 organism-based format Scientific Literature 12. ALA4012338 A Half life in dog at 0.25 mg/kg, iv Canis lupus familiaris 5 ALA4011607 organism-based format Scientific Literature 13. ALA4012348 A Activation of human PXR at 10 uM relative to rifampicin Homo sapiens 26 ALA4011607 single protein format Scientific Literature 14. ALA4012349 A Time-dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated with enzyme in presence of NADPH followed by substrate addition Homo sapiens 9 ALA4011607 assay format Scientific Literature 15. ALA4012350 A Intrinsic clearance in rat liver microsomes at 1 uM after 40 mins by LC-MS/MS assay Rattus norvegicus 4 ALA4011607 assay format Scientific Literature 16. ALA4012351 A Intrinsic clearance in dog liver microsomes at 1 uM after 40 mins by LC-MS/MS assay Canis lupus familiaris 4 ALA4011607 assay format Scientific Literature 17. ALA4012352 A Intrinsic clearance in human liver microsomes at 1 uM after 40 mins by LC-MS/MS assay Homo sapiens 4 ALA4011607 assay format Scientific Literature 18. ALA4012353 A Fraction unbound in rat plasma at 5 uM after 45 mins by LC-MS/MS analysis Rattus norvegicus 5 ALA4011607 cell-free format Scientific Literature 19. ALA4012354 A Fraction unbound in dog plasma at 5 uM after 45 mins by LC-MS/MS analysis Canis lupus familiaris 5 ALA4011607 cell-free format Scientific Literature 20. ALA4012355 A Fraction unbound in human plasma at 5 uM after 45 mins by LC-MS/MS analysis Homo sapiens 4 ALA4011607 cell-free format Scientific Literature