# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3861108 | B | Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after 24 hrs by Griess assay | Mus musculus | 36 | ALA3860061 | cell-based format | Scientific Literature | |
2. | ALA3861109 | B | Inhibition of Src in Sprague-Dawley rat primary mixed mesecephalic neuron/glial cells assessed as suppression of LPS-induced IL-1beta expression at 10 uM preincubated for 1 hr followed by LPS challenge measured after 5 hrs by ELISA | Rattus norvegicus | 4 | ALA3860061 | assay format | Scientific Literature | |
3. | ALA3861110 | B | Inhibition of Src in Sprague-Dawley rat primary mixed mesecephalic neuron/glial cells assessed as suppression of LPS-induced TNFalpha expression at 10 uM preincubated for 1 hr followed by LPS challenge measured after 5 hrs by ELISA | Rattus norvegicus | 4 | ALA3860061 | assay format | Scientific Literature | |
4. | ALA3861111 | B | Inhibition of SRC in Sprague-Dawley rat primary mixed mesecephalic neuron/glial cells assessed as protection against LPS-induced dopaminergic neuro-toxicity by measuring TH expression at 10 uM preincubated for 1 hr followed by LPS challenge measured after 7 days by Western blot analysis | Rattus norvegicus | 4 | ALA3860061 | assay format | Scientific Literature | |
5. | ALA3861112 | A | AUC (0 to infinity) in ICR mouse blood at 50 mg/kg, ig up to 8 hrs by LC/MS/MS analysis | Mus musculus | 4 | ALA3860061 | organism-based format | Scientific Literature | |
6. | ALA3861113 | A | Half life in ICR mouse blood at 50 mg/kg, ig up to 8 hrs by LC/MS/MS analysis | Mus musculus | 4 | ALA3860061 | organism-based format | Scientific Literature | |
7. | ALA3861114 | A | Cmax in ICR mouse blood at 50 mg/kg, ig up to 8 hrs by LC/MS/MS analysis | Mus musculus | 4 | ALA3860061 | organism-based format | Scientific Literature | |
8. | ALA3861115 | A | AUC (0 to infinity) in ICR mouse brain at 50 mg/kg, ig up to 8 hrs by LC/MS/MS analysis | Mus musculus | 4 | ALA3860061 | organism-based format | Scientific Literature | |
9. | ALA3861117 | A | Cmax in ICR mouse brain at 50 mg/kg, ig up to 8 hrs by LC/MS/MS analysis | Mus musculus | 4 | ALA3860061 | organism-based format | Scientific Literature | |
10. | ALA3861118 | A | Drug uptake in ICR mouse plasma at 50 mg/kg, ig after 5 mins by LC/MS/MS analysis | Mus musculus | 4 | ALA3860061 | organism-based format | Scientific Literature | |
11. | ALA3861158 | B | Inhibition of Src in Sprague-Dawley rat primary mixed mesecephalic neuron/glial cells assessed as suppression of LPS-induced microglia activation by measuring Iba-1 expression at 10 uM preincubated for 1 hr followed by LPS challenge measured after 5 hrs by ELISA | Rattus norvegicus | 4 | ALA3860061 | assay format | Scientific Literature |