# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4323334 | Binding | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake at 0.05 uM incubated for 2 mins by LC-MS/MS analysis relative to control empty vector transfected cells | Homo sapiens | 21 | ALA4321821 | cell-based format | Scientific Literature | |
2. | ALA4323335 | Binding | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake at 0.1 uM incubated for 2 mins by LC-MS/MS analysis relative to control empty vector transfected cells | Homo sapiens | 21 | ALA4321821 | cell-based format | Scientific Literature | |
3. | ALA4323336 | Binding | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake at 0.5 uM incubated for 2 mins by LC-MS/MS analysis relative to control empty vector transfected cells | Homo sapiens | 21 | ALA4321821 | cell-based format | Scientific Literature | |
4. | ALA4323337 | Binding | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake at 0.05 to 0.5 uM incubated for 2 mins in presence of 2 mM MPP+ by LC-MS/MS analysis relative to control empty vector transfected cells | Homo sapiens | 9 | ALA4321821 | cell-based format | Scientific Literature | |
5. | ALA4323354 | Binding | Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysis | Homo sapiens | 23 | ALA4321821 | cell-based format | Scientific Literature | |
6. | ALA4323355 | ADME | Passive membrane permeability by LC-MS/MS analysis based PAMPA | 23 | ALA4321821 | assay format | Scientific Literature |