PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT. (Class of assay: confirmatory)
Inhibition of Trichomonas vaginalis uridine nucleoside ribohydrolase using 5-fluorouridine as substrate at 0.04 to 200 uM after 40 mins by NMR spectrometric analysis
Ratio of drug level in milk to serum in jugular and femoral vein-cannulated lactating Sprague-Dawley rat at 0.4 mg/ml, iv administered as infusion in presence of GF120918
Fraction unbound in jugular and femoral vein-cannulated lactating Sprague-Dawley rat serum at 0.4 mg/ml, iv administered as infusion after 8 hrs by equilibrium dialysis method
Fraction unbound in jugular and femoral vein-cannulated lactating Sprague-Dawley rat whole milk at 0.4 mg/ml, iv administered as infusion after 8 hrs by equilibrium dialysis method
Ratio of unbound drug level in whole milk to skim milk in jugular and femoral vein-cannulated lactating Sprague-Dawley rat at 0.4 mg/ml, iv administered as infusion after 8 hrs by equilibrium dialysis method
Drug uptake in jugular and femoral vein-cannulated lactating Sprague-Dawley rat serum at 0.4 mg/ml, iv administered as infusion after 2 hrs by LC-MS analysis
Drug uptake in jugular and femoral vein-cannulated lactating Sprague-Dawley rat serum at 0.4 mg/ml, iv administered as infusion after 2 hrs by LC-MS analysis in presence of GF120918
Drug uptake in jugular and femoral vein-cannulated lactating Sprague-Dawley rat milk at 0.4 mg/ml, iv administered as infusion after 8 hrs by LC-MS analysis
Drug uptake in jugular and femoral vein-cannulated lactating Sprague-Dawley rat milk at 0.4 mg/ml, iv administered as infusion after 8 hrs by LC-MS analysis in presence of GF120918