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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4122878 B Inhibition of recombinant human renin using angiotensinogen as substrate pretreated for 10 mins followed by substrate addition measured after 30 mins in absence of human serum albumin by ELISA Homo sapiens 24 single protein format Scientific Literature 2. ALA4122879 B Inhibition of recombinant human renin using angiotensinogen as substrate pretreated for 10 mins followed by substrate addition measured after 30 mins in presence of human serum albumin by ELISA Homo sapiens 24 single protein format Scientific Literature 3. ALA4122880 B Inhibition of renin in human plasma by radioimmunoassay Homo sapiens 24 single protein format Scientific Literature 4. ALA4122881 P 1-octanol/aqueous buffer partition coefficient, log D of the compound at pH 7.4 by UV-vis/HPLC method 24 small-molecule physicochemical format Scientific Literature 5. ALA4122882 A AUC in rat at 0.1 mg/kg, iv administered as cassette dose by LC-MS/MS analysis Rattus norvegicus 21 organism-based format Scientific Literature 6. ALA4122883 A AUC in rat at 1 mg/kg, po administered as cassette dose by LC-MS/MS analysis Rattus norvegicus 21 organism-based format Scientific Literature 7. ALA4122884 A Clearance in rat at 0.1 mg/kg, iv or 1 mg/kg, po administered as cassette dose by LC-MS/MS analysis Rattus norvegicus 21 organism-based format Scientific Literature 8. ALA4122885 A Oral bioavailability in rat at 1 mg/kg administered as cassette dose by LC-MS/MS analysis Rattus norvegicus 21 organism-based format Scientific Literature 9. ALA4122886 A Permeability of the compound at pH 7.4 buffer after 3 hrs by PAMPA 21 assay format Scientific Literature 10. ALA4122888 B Inhibition of renin in rat plasma Rattus norvegicus 2 assay format Scientific Literature 11. ALA4122889 B Inhibition of renin in monkey plasma Macaca mulatta 2 single protein format Scientific Literature 12. ALA4122890 B Ratio of IC50 for renin in rat plasma to IC50 for renin in monkey plasma 1 assay format Scientific Literature 13. ALA4122891 A AUC in cynomolgus monkey at 0.1 mg/kg, iv administered as cassette dose by LC-MS/MS analysis Macaca fascicularis 2 organism-based format Scientific Literature 14. ALA4122892 A Clearance in cynomolgus monkey at 0.1 mg/kg, iv or 1 mg/kg, po administered as cassette dose by LC-MS/MS analysis Macaca fascicularis 2 organism-based format Scientific Literature 15. ALA4122893 A AUC in cynomolgus monkey at 1 mg/kg, po administered as cassette dose by LC-MS/MS analysis Macaca fascicularis 2 organism-based format Scientific Literature 16. ALA4122894 A Cmax in cynomolgus monkey at 0.1 mg/kg, iv or 1 mg/kg, po administered as cassette dose by LC-MS/MS analysis Macaca fascicularis 2 organism-based format Scientific Literature 17. ALA4122895 A Tmax in cynomolgus monkey at 0.1 mg/kg, iv or 1 mg/kg, po administered as cassette dose by LC-MS/MS analysis Macaca fascicularis 2 organism-based format Scientific Literature 18. ALA4122896 A Oral bioavailability in cynomolgus monkey at 1 mg/kg administered as cassette dose by LC-MS/MS analysis Macaca fascicularis 2 organism-based format Scientific Literature 19. ALA4122897 F Invivo inhibition of plasma renin in po dosed cynomolgus monkey measured at 4 and 24 hrs post dose by radioimmunoassay Macaca fascicularis 1 organism-based format Scientific Literature 20. ALA4122898 F Potency index, ratio of aliskerin effect to test compound effect for invivo inhibition of plasma renin in po dosed cynomolgus monkey Macaca fascicularis 1 organism-based format Scientific Literature