# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4257144 | F | In vivo inhibition of NHE3 in rat assessed as inhibition of 33Pi uptake at 10 mg/kg, po measured up to 120 mins | Rattus norvegicus | 3 | ALA4257082 | organism-based format | Patent Bioactivity Data | |
2. | ALA4257145 | F | In vivo inhibition of NHE3 in rat assessed as inhibition of 33Pi uptake at 10 mg/kg, po measured up to 120 mins in presence of calcium/glucose | Rattus norvegicus | 1 | ALA4257082 | organism-based format | Patent Bioactivity Data | |
3. | ALA4257146 | F | In vivo inhibition of NHE3 in rat assessed as inhibition of 33Pi uptake at 10 mg/kg, po measured up to 120 mins in presence of calcium | Rattus norvegicus | 1 | ALA4257082 | organism-based format | Patent Bioactivity Data | |
4. | ALA5149726 | B | Inhibition of human NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ethyl isopropyl amiloride by BCECF-AM dye based fluorescence assay | Homo sapiens | 46 | ALA5143744 | cell-based format | Scientific Literature | |
5. | ALA5149727 | B | Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ethyl isopropyl amiloride by BCECF-AM dye based fluorescence assay | Rattus norvegicus | 43 | ALA5143744 | cell-based format | Scientific Literature | |
6. | ALA5149766 | F | In vivo inhibition of NEH3 in Sprague-Dawley rat assessed as reduction in sodium excretion in urine at 0.1 to 3 mg/kg, po administered via gavage measured after 16 hrs by ion chromatography | Rattus norvegicus | 6 | ALA5143744 | organism-based format | Scientific Literature | |
7. | ALA5149767 | F | In vivo inhibition of NEH3 in Sprague-Dawley rat assessed as increase in fecal water content at 0.1 to 3 mg/kg, po administered via gavage measured after 6 hrs | Rattus norvegicus | 6 | ALA5143744 | organism-based format | Scientific Literature | |
8. | ALA5149770 | A | Drug recovery in Sprague-Dawley rat feces at 0.1 mg/kg, po administered via gavage measured after 72 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA5143744 | organism-based format | Scientific Literature | |
9. | ALA5149773 | A | Drug metabolism in Sprague-Dawley rat feces at 0.1 mg/kg, po administered via gavage measured after 72 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA5143744 | organism-based format | Scientific Literature | |
10. | ALA5149774 | A | Cmax in Sprague-Dawley rat at 30 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA5143744 | organism-based format | Scientific Literature | |
11. | ALA5149775 | A | Drug metabolism in Sprague-Dawley rat at 30 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA5143744 | organism-based format | Scientific Literature | |
12. | ALA5149776 | T | Inhibition of human ERG at 10 uM relative to control | Homo sapiens | 6 | ALA5143744 | assay format | Scientific Literature |