# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4025640 | P | Stability of the compound in phosphate buffered saline assessed as compound remaining at 5 uM after 48 hrs by HPLC method | 2 | ALA4024709 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA4025641 | A | Stability of the compound in mouse liver microsomes assessed as compound remaining at 5 uM after 6 hrs in absence of NADPH by HPLC method | Mus musculus | 2 | ALA4024709 | assay format | Scientific Literature | |
3. | ALA4025642 | A | Stability of the compound in mouse liver microsomes assessed as compound remaining at 5 uM after 6 hrs in presence of NADPH by HPLC method | Mus musculus | 2 | ALA4024709 | assay format | Scientific Literature | |
4. | ALA4025643 | A | Prodrug activation in mouse liver microsomes assessed as CYP450 reductase-mediated SN-38 release at 5 uM after 6 hrs in presence of NADPH by HPLC method | Mus musculus | 2 | ALA4024709 | assay format | Scientific Literature | |
5. | ALA4025644 | F | Cytotoxicity against human HT-29 cells pretreated for 24 hrs under hypoxic condition followed by compound washout measured after 72 hrs by MTT assay | Homo sapiens | 4 | ALA4024709 | cell-based format | Scientific Literature | |
6. | ALA4025645 | A | Cytotoxicity against human HT-29 cells pretreated for 24 hrs under normoxic condition followed by compound washout measured after 72 hrs by MTT assay | Homo sapiens | 4 | ALA4024709 | cell-based format | Scientific Literature | |
7. | ALA4025646 | U | Selectivity ratio of IC50 for human HT-29 cells under normoxic condition to IC50 for human HT-29 cells under hypoxic condition | Homo sapiens | 4 | ALA4024709 | cell-based format | Scientific Literature | |
8. | ALA4025647 | F | Cytotoxicity against human NCI-H460 cells pretreated for 24 hrs under hypoxic condition followed by compound washout measured after 72 hrs by MTT assay | Homo sapiens | 4 | ALA4024709 | cell-based format | Scientific Literature | |
9. | ALA4025648 | A | Cytotoxicity against human NCI-H460 cells pretreated for 24 hrs under normoxic condition followed by compound washout measured after 72 hrs by MTT assay | Homo sapiens | 4 | ALA4024709 | cell-based format | Scientific Literature | |
10. | ALA4025649 | U | Selectivity ratio of IC50 for human NCI-H460 cells under normoxic condition to IC50 for human NCI-H460 cells under hypoxic condition | Homo sapiens | 4 | ALA4024709 | cell-based format | Scientific Literature |