# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4041600 | B | Inhibition of HCV genotype 1b NK5.1 NS5A in infected human Huh 7.5.1 cells assessed as reduction in viral RNA replication incubated for 3 days by luciferase reporter gene assay | Hepatitis C virus subtype 1b | 16 | assay format | Scientific Literature | ||
2. | ALA4041601 | B | Inhibition of HCV genotype 2a JFH5a replicon NS5A in infected human Huh 7.5.1 cells assessed as reduction in viral RNA replication incubated for 3 days by luciferase reporter gene assay | Hepatitis C virus subtype 2a | 8 | assay format | Scientific Literature | ||
3. | ALA4041602 | A | Cytotoxicity against human Huh7.5.1 cells at 20 uM | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
4. | ALA4041603 | B | Inhibition of human ERG at 10 uM by fluorescence polarization assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
5. | ALA4041604 | A | Metabolic stability in human plasma assessed as compound remaining at 100 uM after 4 hrs incubation by LC-MS/MS analysis | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
6. | ALA4041605 | T | Mutagenicity in Salmonella typhimurium TA98 assessed as revertant colonies/plate in presence of liver S9 fraction at 1000 ug/plate by Ames test (Rvb = 25 +/- 3 No_unit) | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | assay format | Scientific Literature | ||
7. | ALA4041611 | T | Mutagenicity in Salmonella typhimurium TA100 assessed as revertant colonies/plate in presence of liver S9 fraction at 1000 ug/plate by Ames test (Rvb = 129 +/- 3 No_unit) | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | assay format | Scientific Literature | ||
8. | ALA4041612 | T | Mutagenicity in Salmonella typhimurium TA100 assessed as revertant colonies/plate in absence of liver S9 fraction at 1000 ug/plate by Ames test (Rvb = 125 +/- 9 No_unit) | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | assay format | Scientific Literature | ||
9. | ALA4041614 | B | Inhibition of HCV genotype 1b NK5.1 NS5A in infected human Huh 7.5.1 cells assessed as reduction in viral RNA replication by measuring combination index in presence of NS5B inhibitor sofosbuvir at ED50 incubated for 3 days by luciferase reporter gene assay | Hepatitis C virus subtype 1b | 2 | assay format | Scientific Literature | ||
10. | ALA4041615 | A | Metabolic stability in rat plasma assessed as compound remaining at 100 uM after 4 hrs incubation by LC-MS/MS analysis | Rattus norvegicus | 3 | cell-free format | Scientific Literature | ||
11. | ALA4041616 | A | Cmax in rat at 10 mg/kg, po | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
12. | ALA4041617 | A | Half life in rat at 10 mg/kg, po | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
13. | ALA4041618 | A | Oral bioavailability in rat at 10 mg/kg | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
14. | ALA4041619 | A | Cmax in rat at 1 mg/kg, iv | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
15. | ALA4041620 | A | Half life in rat at 1 mg/kg, iv | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
16. | ALA4041621 | T | Mutagenicity in Salmonella typhimurium TA98 assessed as revertant colonies/plate in absence of liver S9 fraction at 1000 ug/plate by Ames test (Rvb = 21 +/- 1 No_unit) | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | assay format | Scientific Literature | ||
17. | ALA4041624 | B | Inhibition of HCV genotype 1b NK5.1 NS5A in infected human Huh 7.5.1 cells assessed as reduction in viral RNA replication by measuring combination index in presence of NS5B inhibitor sofosbuvir at ED75 incubated for 3 days by luciferase reporter gene assay | Hepatitis C virus subtype 1b | 2 | assay format | Scientific Literature | ||
18. | ALA4041625 | B | Inhibition of HCV genotype 1b NK5.1 NS5A in infected human Huh 7.5.1 cells assessed as reduction in viral RNA replication by measuring combination index in presence of NS5B inhibitor sofosbuvir at ED90 incubated for 3 days by luciferase reporter gene assay | Hepatitis C virus subtype 1b | 2 | assay format | Scientific Literature | ||
19. | ALA4041626 | B | Inhibition of HCV genotype 1b NK5.1 NS5A in infected human Huh 7.5.1 cells assessed as reduction in viral RNA replication by measuring combination index in presence of NS5B inhibitor sofosbuvir at ED95 incubated for 3 days by luciferase reporter gene assay | Hepatitis C virus subtype 1b | 2 | assay format | Scientific Literature |