| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4025650 | B | Inhibition of CYP17 in Sprague-Dawley rat testes microsomes using 17-alpha hydroxyprogesterone as substrate and NADPH as cofactor pretreated for 5 mins followed by substrate and cofactor addition after 60 mins by LC/Ms analysis | Rattus norvegicus | 28 | assay format | Scientific Literature | ||
| 2. | ALA4025651 | B | Inhibition of recombinant human CYP17 expressed in human A549 cell membranes using 17-alpha hydroxyprogesterone as substrate and NADPH as cofactor pretreated for 5 mins followed by substrate and cofactor addition after 60 mins by LC/MS analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 3. | ALA4025652 | B | Potency index, ratio of abiraterone IC50 to compound IC50 for CYP17 in Sprague-Dawley rat testes microsomes | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 4. | ALA4025653 | B | Potency index, ratio of abiraterone IC50 to compound IC50 for recombinant human CYP17 expressed in human A549 cell membranes | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4025654 | A | Inhibition of human hepatic CYP3A4 | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 6. | ALA4025655 | A | Inhibition of human hepatic CYP1A2 at 1 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 7. | ALA4025656 | A | Inhibition of human hepatic CYP1A2 at 10 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 8. | ALA4025657 | A | Inhibition of human hepatic CYP2C9 at 1 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 9. | ALA4025658 | A | Inhibition of human hepatic CYP2C9 at 10 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 10. | ALA4025659 | A | Inhibition of human hepatic CYP2C19 at 1 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 11. | ALA4025660 | A | Inhibition of human hepatic CYP2C19 at 10 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 12. | ALA4025661 | A | Inhibition of human hepatic CYP2D6 at 1 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 13. | ALA4025662 | A | Inhibition of human hepatic CYP2D6 at 10 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 14. | ALA4025663 | B | Inhibition of CYP17 in human NCI-H295R cells assessed as reduction in testosterone production at 1 uM measured after 72 hrs relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4025664 | F | Suppression of serum testosterone levels in po dosed Sprague-Dawley rat administered as single dose measured up to 24 hrs post dose by ELISA | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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