| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4003515 | B | Inhibition of PARP12 (unknown origin) | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 2. | ALA4003516 | B | Inhibition of PARP14 (unknown origin) | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 3. | ALA4003517 | B | Inhibition of full length recombinant human N-terminal GST-tagged PARP1 expressed in Baculovirus infected Sf9 cells using TACS-Sapphire as substrate measured after 1 hr by colorimetric assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 4. | ALA4003518 | B | Inhibition of recombinant human N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells measured after 1 hr by chemiluminescence assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 5. | ALA4003519 | B | Inhibition of PARP3 (unknown origin) | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 6. | ALA4003520 | B | Inhibition of PARP4 (unknown origin) | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 7. | ALA4003521 | B | Inhibition of recombinant human N-terminal GST-tagged TNKS1 (1001 to 1327 residues) expressed in baculovirus infected sf9 cells using TACS-Sapphire as substrate measured after 30 mins by colorimetric assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 8. | ALA4003522 | B | Inhibition of recombinant human N-terminal His-GST-tagged TNKS2 (849 to 1166 residues) expressed in baculovirus infected Sf9 cells using biotinylated NAD+ as substrate measured after 2 hrs | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 9. | ALA4003523 | B | Inhibition of PARP10 (unknown origin) | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 10. | ALA4003524 | B | Inhibition of PARP15 (unknown origin) | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 11. | ALA4003525 | B | Inhibition of PARP16 (unknown origin) | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 12. | ALA4003526 | B | Inhibition of tankyrase (unknown origin) expressed in TCF/LEF-HEK293 cells assessed as inhibition of Wnt/beta-catenin signaling pathway in Wnt3a conditioned medium measured after 20 hrs by luciferase reporter gene assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 13. | ALA4003528 | F | Anti-proliferative activity against human DLD1 cells assessed as inhibition of colony formation at 100 nM measured after 18 days under normal serum condition by trypan blue staining based light microscopic analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA4003529 | F | Anti-proliferative activity against human DLD1 cells assessed as inhibition of colony formation at 1 uM measured after 18 days under normal serum condition by trypan blue staining based light microscopic analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA4003532 | A | Effect on glucose uptake in mouse 3T3L1 cells at 1 uM using 2-deoxy-D-[2,6-3H]glucose as substrate pretreated for 1 hr followed substrate addition measured after 5 mins by scintillation counter | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA4003537 | B | Inhibition of TNKS in mouse 3T3L1 cells assessed as upregulation of GLUT4 by measuring increase in insulin-stimulated glucose uptake at 10 to 1000 nM using 2-deoxy-D-[2,6-3H]glucose as substrate pretreated for 1 hr followed by insulin stimulation for 30 mins and subsequent addition of substrate measured after 5 mins by scintillation counter | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4003538 | B | Selectivity ratio of IC50 for full length recombinant human N-terminal GST-tagged PARP1 expressed in Baculovirus infected Sf9 cells to IC50 for recombinant human N-terminal His-GST-tagged TNKS2 (849 to 1166 residues) expressed in Baculovirus infected Sf9 cells | Homo sapiens | 3 | cell-based format | Scientific Literature |
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