Antagonist activity at recombinant human alpha1a adrenergic receptor expressed in human Chem1 cell membrane assessed as reduction in ephinephrine-induced calcium mobilization at 1 uM by fluoforte dye based fluorescence assay relative to ephinephrine
Anti-androgenic activity in citral-induced prostatic hyperplasia Sprague-Dawley rat model assessed as prostate weight at 10 mg/kg, po administered once daily coadministered with citral for 21 days measured 24 hrs last post dose (Rvb = 100%)
Toxicity in citral-induced prostatic hyperplasia Sprague-Dawley rat model assessed as effect on seminal vesicle weight at 10 mg/kg, po administered once daily coadministered with citral for 21 days measured 24 hrs last post dose
Toxicity in citral-induced prostatic hyperplasia Sprague-Dawley rat model assessed as effect on testis weight at 10 mg/kg, po administered once daily coadministered with citral for 21 days measured 24 hrs last post dose
Toxicity in citral-induced prostatic hyperplasia Sprague-Dawley rat model assessed as effect on epididymis weight at 10 mg/kg, po administered once daily coadministered with citral for 21 days measured 24 hrs last post dose
Anti-androgenic activity in citral-induced prostatic hyperplasia Sprague-Dawley rat model assessed increase in distinction between stromal and acinar compartments at 10 mg/kg, po administered once daily coadministered with citral for 21 days measured 24 hrs last post dose by hematoxyline and eosin stainig based light microscopic analysis
Anti-depressant like activity in Swiss albino mouse assessed as reduction in immobility time at 20 mg/kg, po administered 60 mins prior to test measured for 5 mins by forced swim test relative to control
Anti-depressant like activity in Swiss albino mouse assessed as reduction in immobility time at 20 mg/kg, po measured for 5 mins by tail suspension test