| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4038122 | B | Inhibition of human factor 12a using fluorogenic peptide as substrate by fluorescence based assay | Homo sapiens | 3 | ALA4033799 | single protein format | Scientific Literature | |
| 2. | ALA4038124 | P | Aqueous solubility of the compound in buffer | 3 | ALA4033799 | small-molecule physicochemical format | Scientific Literature | ||
| 3. | ALA4038125 | B | Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Homo sapiens | 13 | ALA4033799 | single protein format | Scientific Literature | |
| 4. | ALA4038126 | B | Inhibition of cynomolgus monkey plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Macaca fascicularis | 5 | ALA4033799 | assay format | Scientific Literature | |
| 5. | ALA4038127 | B | Inhibition of recombinant mouse C-terminal 6His-tagged plasma kallikrein (20 to 638 residues) using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Mus musculus | 5 | ALA4033799 | single protein format | Scientific Literature | |
| 6. | ALA4038128 | B | Inhibition of recombinant Sprague-Dawley rat plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Rattus norvegicus | 7 | ALA4033799 | single protein format | Scientific Literature | |
| 7. | ALA4038129 | B | Inhibition of rabbit plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Oryctolagus cuniculus | 5 | ALA4033799 | assay format | Scientific Literature | |
| 8. | ALA4038130 | B | Inhibition of pig plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Sus scrofa | 5 | ALA4033799 | single protein format | Scientific Literature | |
| 9. | ALA4038131 | B | Inhibition of dog plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Canis lupus familiaris | 5 | ALA4033799 | assay format | Scientific Literature | |
| 10. | ALA4038132 | A | Half life in human plasma at 4 uM measured up to 24 hrs by LC-MS/MS analysis | Homo sapiens | 3 | ALA4033799 | cell-free format | Scientific Literature | |
| 11. | ALA4038133 | A | Half life in mouse plasma at 4 uM measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4033799 | cell-free format | Scientific Literature | |
| 12. | ALA4038134 | A | Half life in rat plasma at 4 uM measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4033799 | cell-free format | Scientific Literature | |
| 13. | ALA4038135 | A | Half life in human vitreous humor at 1 uM measured up to 24 hrs by LC-MS/MS analysis | Homo sapiens | 3 | ALA4033799 | tissue-based format | Scientific Literature | |
| 14. | ALA4038138 | B | Inhibition of recombinant human C-terminal His-tagged KLK1 (1 to 262 residues) expressed in HEK293 cells using fluorogenic PFR-AMC peptide as substrate by fluorescence based assay | Homo sapiens | 3 | ALA4033799 | cell-based format | Scientific Literature | |
| 15. | ALA4038139 | B | Inhibition of recombinant human C-terminal 10His-tagged KLK2 (1 to 261 residues) expressed in mouse NS0 cells using fluorogenic PFR-AMC peptide as substrate after 5 mins by fluorescence based assay | Homo sapiens | 3 | ALA4033799 | cell-based format | Scientific Literature | |
| 16. | ALA4038140 | B | Inhibition of recombinant human C-terminal His-tagged KLK6 isoform 1 (1 to 244 residues) expressed in HEK293 cells using fluorogenic Boc-QARAMC peptide as substrate by fluorescence based assay | Homo sapiens | 3 | ALA4033799 | cell-based format | Scientific Literature | |
| 17. | ALA4038141 | B | Inhibition of recombinant human C-terminal 10His-tagged KLK5 (67 to 293 residues) expressed in mouse NS0 cells using fluorogenic Boc-VPR-AMC peptide as substrate after 5 mins by fluorescence based assay | Homo sapiens | 3 | ALA4033799 | cell-based format | Scientific Literature | |
| 18. | ALA4038142 | B | Inhibition of recombinant human C-terminal 10His-tagged KLK12 (18 to 248 residues) expressed in mouse NS0 cells using fluorogenic Boc-VPR-AMC peptide as substrate by fluorescence based assay | Homo sapiens | 3 | ALA4033799 | cell-based format | Scientific Literature | |
| 19. | ALA4038143 | B | Inhibition of recombinant human C-terminal polyHis-tagged KLK13 (1 to 262 residues) expressed in HEK293 cells using fluorogenic Boc-VPR-AMC peptide as substrate by fluorescence based assay | Homo sapiens | 3 | ALA4033799 | cell-based format | Scientific Literature | |
| 20. | ALA4038144 | B | Inhibition of recombinant human C-terminal 10His-tagged KLK14 (19 to 248 residues) expressed in mouse NS0 cells using fluorogenic Boc-VPR-AMC peptide as substrate by fluorescence based assay | Homo sapiens | 3 | ALA4033799 | cell-based format | Scientific Literature |
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