# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4012882 | B | Binding affinity to TNKS1 in human Jurkat cell extract after 45 mins by mass spectrometric analysis | Homo sapiens | 6 | ALA4011625 | single protein format | Scientific Literature | |
2. | ALA4012883 | B | Binding affinity to TNKS2 in human Jurkat cell extract after 45 mins by mass spectrometric analysis | Homo sapiens | 6 | ALA4011625 | single protein format | Scientific Literature | |
3. | ALA4012884 | B | Binding affinity to PARP1 in human Jurkat cell extract after 45 mins by mass spectrometric analysis | Homo sapiens | 5 | ALA4011625 | single protein format | Scientific Literature | |
4. | ALA4012885 | B | Binding affinity to PARP2 in human Jurkat cell extract after 45 mins by mass spectrometric analysis | Homo sapiens | 5 | ALA4011625 | single protein format | Scientific Literature | |
5. | ALA4012886 | B | Binding affinity to PARP4 in human Jurkat cell extract after 45 mins by mass spectrometric analysis | Homo sapiens | 5 | ALA4011625 | single protein format | Scientific Literature | |
6. | ALA4012887 | B | Binding affinity to PARP11 in human Jurkat cell extract after 45 mins by mass spectrometric analysis | Homo sapiens | 5 | ALA4011625 | single protein format | Scientific Literature | |
7. | ALA4012888 | B | Binding affinity to PARP13 in human Jurkat cell extract after 45 mins by mass spectrometric analysis | Homo sapiens | 4 | ALA4011625 | assay format | Scientific Literature | |
8. | ALA4012889 | B | Binding affinity to PARP14 in human Jurkat cell extract after 45 mins by mass spectrometric analysis | Homo sapiens | 5 | ALA4011625 | single protein format | Scientific Literature | |
9. | ALA4012890 | B | Binding affinity to PARP16 in human Jurkat cell extract after 45 mins by mass spectrometric analysis | Homo sapiens | 5 | ALA4011625 | single protein format | Scientific Literature | |
10. | ALA4012891 | B | Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assay | Homo sapiens | 37 | ALA4011625 | cell-based format | Scientific Literature | |
11. | ALA4012892 | B | Selectivity ratio of IC50 for PARP1 in human Jurkat cell extract to IC50 for TNKS1 in human Jurkat cell extract | Homo sapiens | 3 | ALA4011625 | assay format | Scientific Literature | |
12. | ALA4012893 | B | Selectivity ratio of IC50 for PARP1 in human Jurkat cell extract to IC50 for TNKS2 in human Jurkat cell extract | Homo sapiens | 3 | ALA4011625 | assay format | Scientific Literature | |
13. | ALA4012894 | B | Binding affinity to PARP10 in human Jurkat cell extract after 45 mins by mass spectrometric analysis | Homo sapiens | 3 | ALA4011625 | single protein format | Scientific Literature | |
14. | ALA4012895 | B | Inhibition of TNKS1 (unknown origin) expressed in HEK293 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in wnt3a ligand-induced Wnt-dependent increase in beta-catenin preincubated for 1 hr followed by wnt3a ligand stimulation for 24 hrs by luciferase reporter gene assay | Homo sapiens | 37 | ALA4011625 | cell-based format | Scientific Literature | |
15. | ALA4012896 | P | Kinetic aqueous solubility of the compound in PBS by chemiluminescent nitrogen detection method | 37 | ALA4011625 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA4012897 | B | Inhibition of His-tagged TNKS1 (1091 to 1325 residues) (unknown origin) assessed as reduction in PARsylation of GST-tev-Axin2 preincubated for 30 mins followed by GST-tev-Axin2 addition measured after 2 hrs in presence of NAD | Homo sapiens | 2 | ALA4011625 | single protein format | Scientific Literature | |
17. | ALA4012898 | B | Inhibition of human PARP1 using biotin-histone as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr in presence of NAD | Homo sapiens | 1 | ALA4011625 | single protein format | Scientific Literature | |
18. | ALA4012899 | B | Selectivity ratio of IC50 for PARP2 in human Jurkat cell extract to IC50 for TNKS1 in human Jurkat cell extract | Homo sapiens | 2 | ALA4011625 | assay format | Scientific Literature | |
19. | ALA4012900 | B | Selectivity ratio of IC50 for PARP4 in human Jurkat cell extract to IC50 for TNKS1 in human Jurkat cell extract | Homo sapiens | 2 | ALA4011625 | assay format | Scientific Literature | |
20. | ALA4012901 | B | Selectivity ratio of IC50 for PARP10 in human Jurkat cell extract to IC50 for TNKS1 in human Jurkat cell extract | Homo sapiens | 2 | ALA4011625 | assay format | Scientific Literature |