| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4037806 | A | Half life in human liver microsomes at 10 uM by LC-MS/MS analysis | Homo sapiens | 26 | ALA4033790 | assay format | Scientific Literature | |
| 2. | ALA4037807 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 10 uM after 60 mins by LC-MS analysis | Homo sapiens | 26 | ALA4033790 | assay format | Scientific Literature | |
| 3. | ALA4037808 | A | Half life in mouse liver microsomes at 10 uM by LC-MS/MS analysis | Mus musculus | 26 | ALA4033790 | assay format | Scientific Literature | |
| 4. | ALA4037809 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 10 uM after 60 mins by LC-MS analysis | Mus musculus | 26 | ALA4033790 | assay format | Scientific Literature | |
| 5. | ALA4037810 | P | Aqueous solubility of the compound in DI water at pH 7 after 2 hrs by LC-MS analysis | 8 | ALA4033790 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4037811 | P | Solubility of the compound in 0.01M HCl at pH 2 after 2 hrs by LC-MS analysis | 8 | ALA4033790 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4037852 | T | Neurotoxicity in Swiss Webster mouse assessed as induction of motor impairment at 40 mg/kg administered via oral gavage measured after 10 to 60 mins by rotarod method | Mus musculus | 18 | ALA4033790 | organism-based format | Scientific Literature | |
| 8. | ALA4219578 | B | Displacement of [3H]Ro15-1788 from human GABAA receptor alpha1beta3gamma2 expressed in LTK cells preincubated for 30 secs measured every 15 mins at -60 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 9. | ALA4219580 | B | Positive allosteric modulation of recombinant human GABAA receptor alpha1beta3gamma2 expressed in Xenopus oocytes assessed as potentiation of GABA induced chloride current response relative to GABA | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 10. | ALA4219581 | B | Displacement of [3H]Ro15-1788 from human GABAA receptor alpha2beta3gamma2 expressed in LTK cells preincubated for 30 secs measured every 15 mins at -60 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 11. | ALA4219582 | B | Displacement of [3H]Ro15-1788 from human GABAA receptor alpha3beta3gamma2 expressed in LTK cells preincubated for 30 secs measured every 15 mins at -60 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 12. | ALA4219583 | B | Displacement of [3H]Ro15-4313 from human GABAA receptor alpha4beta3gamma2 expressed in LTK cells preincubated for 30 secs measured every 15 mins at -60 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 13. | ALA4219584 | B | Displacement of [3H]Ro15-1788 from human GABAA receptor alpha5beta3gamma2 expressed in LTK cells preincubated for 30 secs measured every 15 mins at -60 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 14. | ALA4219585 | B | Displacement of [3H]Ro15-1788 from human GABAA receptor alpha6beta3gamma2 expressed in LTK cells preincubated for 30 secs measured every 15 mins at -60 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 15. | ALA4219586 | B | Positive allosteric modulation of recombinant human GABAA receptor alpha2beta3gamma2 expressed in Xenopus oocytes assessed as potentiation of GABA induced chloride currents relative to GABA | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 16. | ALA4219587 | B | Positive allosteric modulation of recombinant human GABAA receptor alpha3beta3gamma2 expressed in Xenopus laevis oocytes assessed as potentiation of GABA induced chloride currents relative to GABA | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 17. | ALA4219588 | B | Positive allosteric modulation of recombinant human GABAA receptor alpha4beta3gamma2 expressed in Xenopus laevis oocytes assessed as potentiation of GABA induced chloride currents relative to GABA | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 18. | ALA4219589 | B | Positive allosteric modulation of recombinant human GABAA receptor alpha5beta3gamma2 expressed in Xenopus laevis oocytes assessed as potentiation of GABA induced chloride currents relative to GABA | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 19. | ALA4219590 | B | Positive allosteric modulation of recombinant human GABAA receptor alpha6beta3gamma2 expressed in Xenopus oocytes assessed as potentiation of GABA induced chloride currents relative to GABA | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 20. | ALA4367978 | B | Positive allosteric modulator activity at rat alpha1beta3 GABA-A receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current at 10 uM co-applied with GABA at concentration of EC3-5 at -60 mV holding potential by two-microelectrode voltage clamp method relative to control | Rattus norvegicus | 8 | ALA4364311 | cell-based format | Scientific Literature |
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