| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4031292 | A | Half life in rat liver microsome preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4028864 | microsome format | Scientific Literature | |
| 2. | ALA4031293 | A | Clearance in Wistar rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4028864 | organism-based format | Scientific Literature | |
| 3. | ALA4031294 | B | Selectivity ratio of IC50 for C-terminal His tagged human recombinant HDAC8 (1 to 377 residues) expressed in Baculovirus infected insect cells to IC50 for N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in Baculovirus infected insect cells | Homo sapiens | 1 | ALA4028864 | cell-based format | Scientific Literature | |
| 4. | ALA4031295 | A | Cytotoxicity against human AC10 cells assessed as cell viability at 100 uM after 24 hrs by CellTiter-Glo assay relative to control | Homo sapiens | 1 | ALA4028864 | cell-based format | Scientific Literature | |
| 5. | ALA4031296 | P | Thermodynamic aqueous solubility of the compound at pH 7.4 after 3 hrs by UV absorbance based assay | 1 | ALA4028864 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4031297 | P | Thermodynamic aqueous solubility of the compound at pH 7.4 after 24 hrs by UV absorbance based assay | 1 | ALA4028864 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4031298 | B | Inhibition of C-terminal His tagged human recombinant HDAC8 (1 to 377 residues) expressed in Baculovirus infected insect cells in presence of ATP | Homo sapiens | 2 | ALA4028864 | cell-based format | Scientific Literature | |
| 8. | ALA4031300 | B | Inhibition of HDAC9 (unknown origin) at 10 uM in presence of ATP relative to control | Homo sapiens | 1 | ALA4028864 | single protein format | Scientific Literature | |
| 9. | ALA4031301 | A | Cytotoxicity against TAMH cells assessed as cell viability after 24 hrs by CellTiter-Glo assay | Mus musculus | 4 | ALA4028864 | cell-based format | Scientific Literature | |
| 10. | ALA4031302 | B | Inhibition of C-terminal FLAG His tagged full length human recombinant HDAC1 (1 to 482 residues) expressed in baculovirus infected sf21 cells using RHKKAc as substrate in presence of ATP | Homo sapiens | 10 | ALA4028864 | cell-based format | Scientific Literature | |
| 11. | ALA4031303 | B | Inhibition of C-terminal FLAG His tagged full length human recombinant HDAC1 (1 to 482 residues) expressed in baculovirus infected sf21 cells at 10 uM using RHKKAc as substrate in presence of ATP relative to control | Homo sapiens | 13 | ALA4028864 | cell-based format | Scientific Literature | |
| 12. | ALA4031304 | B | Inhibition of N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using RHKKAc as substrate in presence of ATP | Homo sapiens | 13 | ALA4028864 | cell-based format | Scientific Literature | |
| 13. | ALA4031305 | B | Inhibition of human JAK2 using poly[Glu:Tyr] as substrate in presence of [gamma-33P]-ATP | Homo sapiens | 13 | ALA4028864 | single protein format | Scientific Literature | |
| 14. | ALA4031306 | B | Binding affinity to N-terminal His tagged human recombinant JAK2 (1014 to 1132 residues) expressed in Escherichia coli after 60 to 90 mins by LC/MS analysis | Homo sapiens | 10 | ALA4028864 | assay format | Scientific Literature | |
| 15. | ALA4031307 | B | Inhibition of human JAK1 using poly[Glu:Tyr] as substrate in presence of [gamma-33P]-ATP | Homo sapiens | 2 | ALA4028864 | single protein format | Scientific Literature | |
| 16. | ALA4031308 | A | Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate in presence of [gamma-33P]-ATP | Homo sapiens | 2 | ALA4028864 | single protein format | Scientific Literature | |
| 17. | ALA4031309 | B | Inhibition of human TYK2 using KKSRGDYMTMQIG as substrate in presence of [gamma-33P]-ATP | Homo sapiens | 2 | ALA4028864 | single protein format | Scientific Literature | |
| 18. | ALA4031310 | B | Inhibition of human FLT3 using EAIYAAPFAKKK as substrate at 1 uM in presence of [gamma-33P]-ATP relative to control | Homo sapiens | 2 | ALA4028864 | single protein format | Scientific Literature | |
| 19. | ALA4031311 | B | Inhibition of wild type human JAK2 (A829 to G1132 residues) expressed in mammalian cells assessed as residual activity at 1 uM by KINOMEscan assay relative to control | Homo sapiens | 1 | ALA4028864 | cell-based format | Scientific Literature | |
| 20. | ALA4031312 | A | Inhibition of wild type human JAK3 (I781 to S1124 residues) expressed in mammalian cells assessed as residual activity at 1 uM by KINOMEscan assay relative to control | Homo sapiens | 1 | ALA4028864 | cell-based format | Scientific Literature |
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