# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4027521 | B | Selectivity index, ratio of IC50 for recombinant human ACC2 to IC50 for recombinant human ACC1 | Homo sapiens | 4 | ALA4024776 | assay format | Scientific Literature | |
2. | ALA4027523 | B | Inhibition of recombinant human ACC1 expressed in SF-9 cells preincubated for 60 mins followed by addition of substrate solution containing acetyl-CoA after 30 mins by measuring malonyl 13C3-CoA by RapidFire mass spectrometry | Homo sapiens | 17 | ALA4024776 | cell-based format | Scientific Literature | |
3. | ALA4027524 | B | Inhibition of recombinant human ACC2 expressed in SF-9 cells preincubated for 60 mins followed by addition of substrate solution containing acetyl-CoA after 30 mins by measuring malonyl 13C3-CoA by RapidFire mass spectrometry | Homo sapiens | 17 | ALA4024776 | cell-based format | Scientific Literature | |
4. | ALA4027525 | B | Inhibition of ACC1 in human HCT116 cells assessed as reduction of [14C]acetate uptake preincubated for 60 mins followed by addition of [14C]acetate and measured after 2 hrs by scintillation counting analysis | Homo sapiens | 17 | ALA4024776 | cell-based format | Scientific Literature | |
5. | ALA4027527 | P | Solubility of the compound at pH 6.8 | 14 | ALA4024776 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4027528 | A | Inhibition of CYP2C8 (unknown origin) at 10 uM | Homo sapiens | 12 | ALA4024776 | single protein format | Scientific Literature | |
7. | ALA4027529 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM | Homo sapiens | 12 | ALA4024776 | single protein format | Scientific Literature | |
8. | ALA4410464 | T | Toxicity in BALB/cA mouse assessed as reduction in body weight at 100 mg/kg, po administered bid for 5 days | Mus musculus | 2 | ALA4406889 | organism-based format | Scientific Literature | |
9. | ALA4410465 | B | Inhibition of mouse His-tagged ACC1 expressed in baculovirus infected SF9 cells using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry | Mus musculus | 2 | ALA4406889 | cell-based format | Scientific Literature | |
10. | ALA4410466 | B | Inhibition of mouse His-tagged ACC2 expressed in baculovirus infected SF9 cells using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry | Mus musculus | 2 | ALA4406889 | cell-based format | Scientific Literature | |
11. | ALA4410467 | B | Inhibition of recombinant human His-tagged ACC1 expressed in baculovirus infected SF9 cells using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry | Homo sapiens | 4 | ALA4406889 | cell-based format | Scientific Literature | |
12. | ALA4410468 | B | Inhibition of recombinant human His-tagged ACC2 expressed in baculovirus infected SF9 cells using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry | Homo sapiens | 4 | ALA4406889 | cell-based format | Scientific Literature | |
13. | ALA4410469 | B | Selectivity index, ratio of IC50 for recombinant human His-tagged ACC2 expressed in baculovirus infected SF9 cells to IC50 for recombinant human His-tagged ACC1 expressed in baculovirus infected SF9 cells | Homo sapiens | 4 | ALA4406889 | cell-based format | Scientific Literature | |
14. | ALA4410470 | B | Inhibition of recombinant human His-tagged ACC1 expressed in baculovirus infected SF9 cells at 10 uM using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry relative to control | Homo sapiens | 2 | ALA4406889 | cell-based format | Scientific Literature | |
15. | ALA4410471 | B | Inhibition of recombinant human His-tagged ACC2 expressed in baculovirus infected SF9 cells at 10 uM using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry relative to control | Homo sapiens | 2 | ALA4406889 | cell-based format | Scientific Literature | |
16. | ALA4410473 | A | Permeability of compound at pH 5 by PAMPA assay | 2 | ALA4406889 | assay format | Scientific Literature | ||
17. | ALA4410474 | A | Metabolic stability in human Liver microsomes | Homo sapiens | 2 | ALA4406889 | microsome format | Scientific Literature | |
18. | ALA4410475 | A | Metabolic stability in mouse Liver microsomes | Mus musculus | 2 | ALA4406889 | microsome format | Scientific Literature | |
19. | ALA4410480 | A | Cmax in ICR mouse at 0.1 mg/kg, iv | Mus musculus | 2 | ALA4406889 | organism-based format | Scientific Literature | |
20. | ALA4410481 | A | AUC (0 to 8 hrs) in ICR mouse at 1 mg/kg, po | Mus musculus | 2 | ALA4406889 | organism-based format | Scientific Literature |