# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3993868 | B | Binding affinity to human IgG1-fused Siglec-7-Fc assessed as inhibition of Siglec-7-Fc binding to RBC preincubated for 10 mins followed by RBC addition measured after 20 mins by FACS analysis relative to sodium (4S,5R,6R)-5-acetamido-4-hydroxy-2-methoxy-6-((1R,2R)-1,2,3 trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylate | Homo sapiens | 36 | single protein format | Scientific Literature | ||
2. | ALA3993869 | B | Binding affinity to human IgG1-fused Siglec-7-Fc assessed as inhibition of Siglec-7-Fc binding to RBC preincubated for 10 mins followed by RBC addition measured after 20 mins by FACS analysis | Homo sapiens | 6 | single protein format | Scientific Literature | ||
3. | ALA3993870 | B | Binding affinity to human IgG1-fused Siglec-9-Fc assessed as inhibition of Siglec-9-Fc binding to K562 cells preincubated for 10 mins followed by K562 cell addition measured after 20 mins by FACS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
4. | ALA3993871 | B | Selectivity ratio of IC50 for human IgG1-fused Siglec-9-Fc binding to human K562 cells to IC50 for human IgG1-fused Siglec-7-Fc binding to human K562 cells | Homo sapiens | 1 | assay format | Scientific Literature | ||
5. | ALA3993872 | B | Binding affinity to human IgG1-fused Siglec-7-Fc measured after 2.5 hrs by ELISA | Homo sapiens | 4 | single protein format | Scientific Literature | ||
6. | ALA3993873 | B | Binding affinity to human IgG1-fused Siglec-7-Fc measured after 2.5 hrs by ELISA relative to 3'sialyllactose | Homo sapiens | 3 | single protein format | Scientific Literature | ||
7. | ALA3993874 | A | Cytotoxicity against human NK cells assessed as viable cells up to 10 mM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA3993875 | A | Cytotoxicity against human K562 cells assessed as viable cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA3993876 | B | Binding affinity to Siglec-7 in IL-2 activated human NK cells assessed as increase in NK cell-mediated 51Cr labeled human MEL1106 cell lysis by measuring 51Cr release preincubated for 15 mins followed by MEL1106 cell addition measured after 4 hrs by gamma-counting method | Homo sapiens | 1 | assay format | Scientific Literature | ||
10. | ALA3993877 | B | Ratio of 3'sialyllactose Kd to relative inhibitory potency of test compound for human IgG1-fused Siglec-7-Fc by ELISA | Homo sapiens | 2 | single protein format | Scientific Literature | ||
11. | ALA3993878 | A | Cytotoxicity against human MEL1106 cells assessed as viable cells | Homo sapiens | 1 | cell-based format | Scientific Literature |