# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4015182 | B | Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as increase in intracellular calcium level measured for 2.5 mins by Fluo-8-AM dye-based fluorescence assay | Mus musculus | 16 | cell-based format | Scientific Literature | ||
2. | ALA4015183 | B | Antagonist activity at mouse TRPC4beta expressed in HEK293 cells co-expressing MOR decrease in DAMGO-evoked intracellular calcium level by Fluo-8-AM dye-based fluorescence assay | Mus musculus | 16 | cell-based format | Scientific Literature | ||
3. | ALA4015184 | B | Agonist activity at human TRPC3 expressed in HEK293 cells assessed as induction of membrane depolarization measured for 2.5 mins in presence of 0.5 mM Ca2+ by FLIPR membrane potential dye-based fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
4. | ALA4015193 | B | Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as peak current changes at +80 mV by whole cell patch-clamp method | Mus musculus | 4 | cell-based format | Scientific Literature | ||
5. | ALA4015195 | B | Agonist activity at human TRPC7 expressed in HEK293 cells assessed as increase in intracellular calcium level measured for 2.5 mins in presence of 2 mM Ca2+ by Fluo8-AM dye-based fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
6. | ALA4015197 | B | Agonist activity at mouse TRPC4beta expressed in HEK293 cells co-expressing MOR assessed as induction of membrane depolarization at 33 uM measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
7. | ALA4015198 | B | Agonist activity at human TRPC5 expressed in HEK293 cells assessed as induction of membrane depolarization at 33 uM measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
8. | ALA4015199 | B | Agonist activity at mouse TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye based fluorescence assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
9. | ALA4015200 | B | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye based fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
10. | ALA4015201 | B | Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye based fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
11. | ALA4015202 | B | Agonist activity at mouse TRPV3 expressed in HEK293 cells assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye based fluorescence assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
12. | ALA4015203 | B | Agonist activity at human TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye based fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
13. | ALA4015204 | B | Agonist activity at human TRPM5 expressed in HEK293 cells assessed as induction of membrane depolarization at 33 uM measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
14. | ALA4015210 | B | Agonist activity at mouse TRPC4beta expressed in HEK293 cells co-expressing MOR assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye-based fluorescence assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
15. | ALA4015211 | B | Antagonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as channel desensitization at 20 to 100 uM at +80 mV in presence of 0.1 mM Ca2+ by whole cell patch-clamp method | Mus musculus | 4 | cell-based format | Scientific Literature |