# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4015182 | B | Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as increase in intracellular calcium level measured for 2.5 mins by Fluo-8-AM dye-based fluorescence assay | Mus musculus | 16 | ALA4014306 | cell-based format | Scientific Literature | |
2. | ALA4015183 | B | Antagonist activity at mouse TRPC4beta expressed in HEK293 cells co-expressing MOR decrease in DAMGO-evoked intracellular calcium level by Fluo-8-AM dye-based fluorescence assay | Mus musculus | 16 | ALA4014306 | cell-based format | Scientific Literature | |
3. | ALA4015184 | B | Agonist activity at human TRPC3 expressed in HEK293 cells assessed as induction of membrane depolarization measured for 2.5 mins in presence of 0.5 mM Ca2+ by FLIPR membrane potential dye-based fluorescence assay | Homo sapiens | 4 | ALA4014306 | cell-based format | Scientific Literature | |
4. | ALA4015186 | B | Inhibition of mouse TRPC4beta expressed in HEK293 cells co-expressing MOR assessed as decrease in DAMGO-evoked membrane depolarization at 22 uM preincubated for 2 mins followed by DAMGO addition measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay relative to control | Mus musculus | 2 | ALA4014306 | cell-based format | Scientific Literature | |
5. | ALA4015187 | B | Inhibition of mouse TRPM8 expressed in HEK293 cells assessed as decrease in methanol-evoked increase in intracellular calcium level at 22 uM preincubated for 2 mins followed by methanol addition measured for 2.5 mins by Fluo8-AM dye-based fluorescence assay relative to control | Mus musculus | 3 | ALA4014306 | cell-based format | Scientific Literature | |
6. | ALA4015191 | B | Agonist activity at TRPC3 in rat primary glomerular mesangial cells assessed as increase in intracellular calcium level at 1 uM by Fluo4-AM dye-based fluorescence assay | Rattus norvegicus | 1 | ALA4014306 | cell-based format | Scientific Literature | |
7. | ALA4015192 | B | Agonist activity at TRPC6 in rat primary glomerular mesangial cells assessed as increase in intracellular calcium level at 1 uM by Fluo4-AM dye-based fluorescence assay | Rattus norvegicus | 1 | ALA4014306 | cell-based format | Scientific Literature | |
8. | ALA4015193 | B | Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as peak current changes at +80 mV by whole cell patch-clamp method | Mus musculus | 4 | ALA4014306 | cell-based format | Scientific Literature | |
9. | ALA4015195 | B | Agonist activity at human TRPC7 expressed in HEK293 cells assessed as increase in intracellular calcium level measured for 2.5 mins in presence of 2 mM Ca2+ by Fluo8-AM dye-based fluorescence assay | Homo sapiens | 4 | ALA4014306 | cell-based format | Scientific Literature | |
10. | ALA4015196 | B | Agonist activity at TRPC3 in rat primary glomerular mesangial cells assessed as increase in intracellular calcium level at 1 uM in presence of TRPC inhibitor 2-ABP by Fluo4-AM dye-based fluorescence assay | Rattus norvegicus | 1 | ALA4014306 | cell-based format | Scientific Literature | |
11. | ALA4015197 | B | Agonist activity at mouse TRPC4beta expressed in HEK293 cells co-expressing MOR assessed as induction of membrane depolarization at 33 uM measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay | Mus musculus | 4 | ALA4014306 | cell-based format | Scientific Literature | |
12. | ALA4015198 | B | Agonist activity at human TRPC5 expressed in HEK293 cells assessed as induction of membrane depolarization at 33 uM measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay | Homo sapiens | 4 | ALA4014306 | cell-based format | Scientific Literature | |
13. | ALA4015199 | B | Agonist activity at mouse TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye based fluorescence assay | Mus musculus | 4 | ALA4014306 | cell-based format | Scientific Literature | |
14. | ALA4015200 | B | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4014306 | cell-based format | Scientific Literature | |
15. | ALA4015201 | B | Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4014306 | cell-based format | Scientific Literature | |
16. | ALA4015202 | B | Agonist activity at mouse TRPV3 expressed in HEK293 cells assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye based fluorescence assay | Mus musculus | 4 | ALA4014306 | cell-based format | Scientific Literature | |
17. | ALA4015203 | B | Agonist activity at human TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4014306 | cell-based format | Scientific Literature | |
18. | ALA4015204 | B | Agonist activity at human TRPM5 expressed in HEK293 cells assessed as induction of membrane depolarization at 33 uM measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay | Homo sapiens | 4 | ALA4014306 | cell-based format | Scientific Literature | |
19. | ALA4015210 | B | Agonist activity at mouse TRPC4beta expressed in HEK293 cells co-expressing MOR assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye-based fluorescence assay | Mus musculus | 4 | ALA4014306 | cell-based format | Scientific Literature | |
20. | ALA4015211 | B | Antagonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as channel desensitization at 20 to 100 uM at +80 mV in presence of 0.1 mM Ca2+ by whole cell patch-clamp method | Mus musculus | 4 | ALA4014306 | cell-based format | Scientific Literature |