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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4051944 A Disruption of food stimulated gallbladder emptying and motility in C57BL6 mouse assessed as ejection fraction at 20 mg/kg, po administered post 4 hrs of fasting followed by 2 hrs of refeeding (Rvb = 30%) Mus musculus 1 ALA4049444 organism-based format Scientific Literature 2. ALA4051945 F Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay relative to lithocholic acid Homo sapiens 27 ALA4049444 cell-based format Scientific Literature 3. ALA4051946 F Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay Homo sapiens 32 ALA4049444 cell-based format Scientific Literature 4. ALA4051947 F Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay relative to lithocholic acid Mus musculus 28 ALA4049444 cell-based format Scientific Literature 5. ALA4051948 F Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay Mus musculus 32 ALA4049444 cell-based format Scientific Literature 6. ALA4051950 P 1-octanol/phosphate buffer solution partition coefficient, log D of the compound at pH 7.4 for 2 hrs by LC-MS/MS method 4 ALA4049444 small-molecule physicochemical format Scientific Literature 7. ALA4051951 A Half life in CD-1 mouse liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis Mus musculus 4 ALA4049444 assay format Scientific Literature 8. ALA4051952 A Intrinsic clearance in CD-1 mouse liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis Mus musculus 4 ALA4049444 assay format Scientific Literature 9. ALA4051953 A Apparent permeability from apical to basolateral side in human Caco2 cells at 10 uM after 1 hr by LC-MS/MS analysis Homo sapiens 3 ALA4049444 cell-based format Scientific Literature 10. ALA4051954 A Apparent permeability from basolateral to apical side in human Caco2 cells at 10 uM after 1 hr by LC-MS/MS analysis Homo sapiens 3 ALA4049444 cell-based format Scientific Literature 11. ALA4051957 A Apparent permeability from apical to basolateral side in human Caco2 cells assessed as drug recovery at 10 uM after 1 hr by LC-MS/MS analysis Homo sapiens 3 ALA4049444 cell-based format Scientific Literature 12. ALA4051958 A Apparent permeability from basolateral to apical side in human Caco2 cells assessed as drug recovery at 10 uM after 1 hr by LC-MS/MS analysis Homo sapiens 3 ALA4049444 cell-based format Scientific Literature 13. ALA4051960 F Antidiabetic activity in C57BL6 mouse assessed as increase in GLP-1 (7 to 36 residues) secretion at 20 mg/kg, po via gavage administered at 2, 4, 6 hrs followed by addition of sitagliptin for 15 mins measured after 45 mins by ELISA method relative to control Mus musculus 2 ALA4049444 organism-based format Scientific Literature 14. ALA4051962 A Cmax in C57BL6/J mouse plasma at 20 mg/kg, po by LC-MS/MS analysis Mus musculus 2 ALA4049444 organism-based format Scientific Literature 15. ALA4051963 A Cmax in C57BL6/J mouse liver at 20 mg/kg, po by LC-MS/MS analysis Mus musculus 2 ALA4049444 organism-based format Scientific Literature 16. ALA4051964 A Cmax in C57BL6/J mouse gallbladder at 20 mg/kg, po by LC-MS/MS analysis Mus musculus 2 ALA4049444 organism-based format Scientific Literature 17. ALA4051965 A Tmax in C57BL6/J mouse at 20 mg/kg, po by LC-MS/MS analysis Mus musculus 2 ALA4049444 organism-based format Scientific Literature 18. ALA4051966 A Half life in C57BL6/J mouse at 20 mg/kg, po by LC-MS/MS analysis Mus musculus 2 ALA4049444 organism-based format Scientific Literature 19. ALA4051967 A AUC in C57BL6/J mouse at 20 mg/kg, po by LC-MS/MS analysis Mus musculus 2 ALA4049444 organism-based format Scientific Literature 20. ALA4051968 A Drug recovery in C57BL6/J mouse feces at 20 mg/kg, po after 24 hrs by LC-MS/MS analysis Mus musculus 2 ALA4049444 organism-based format Scientific Literature