The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
The page will load shortly, Thanks for your patience!
# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4015040 B Inhibition of human PI3K p85beta (1 to 724 residues) by ADP Glo HTS assay Homo sapiens 1 single protein format Scientific Literature 2. ALA4015041 B Inhibition of PI3Kgamma in mouse RAW264 cells assessed as decrease in AKT phosphorylation at Ser473 Mus musculus 1 cell-based format Scientific Literature 3. ALA4015042 P Lipophilicity, log D of the compound at pH 7.4 12 small-molecule physicochemical format Scientific Literature 4. ALA4015043 B Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrs Homo sapiens 11 assay format Scientific Literature 5. ALA4015044 B Inhibition of PI3Kalpha mutant in human BT474 cells assessed as decrease in AKT phosphorylation at Thr308 after 2 hrs Homo sapiens 11 cell-based format Scientific Literature 6. ALA4015045 A Intrinsic clearance in human hepatocytes assessed per million cells Homo sapiens 11 cell-based format Scientific Literature 7. ALA4015046 A Apparent permeability across apical to basolateral side in human Caco2 cells Homo sapiens 6 cell-based format Scientific Literature 8. ALA4015047 A AUC in mouse at 30 umol/kg, po Mus musculus 6 assay format Scientific Literature 9. ALA4015048 B Inhibition of recombinant human PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in presence of ATP by Kinase Glo luminescence assay Homo sapiens 3 single protein format Scientific Literature 10. ALA4015049 B Inhibition of recombinant human PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in presence of ATP by Kinase Glo luminescence assay Homo sapiens 3 single protein format Scientific Literature 11. ALA4015050 B Inhibition of recombinant human PI3Kgamma using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in presence of ATP by Kinase Glo luminescence assay Homo sapiens 3 single protein format Scientific Literature 12. ALA4015051 B Inhibition of recombinant human PI3Kdelta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in presence of ATP by Kinase Glo luminescence assay Homo sapiens 3 single protein format Scientific Literature 13. ALA4015052 B Inhibition of PI3Kdelta in human JeKo1 B cells assessed as decrease in AKT phosphorylation at Ser473 measured after 1 hr Homo sapiens 1 cell-based format Scientific Literature 14. ALA4015053 A Clearance in mouse blood at 5 umol/kg, iv or 30 umol/kg, po Mus musculus 2 organism-based format Scientific Literature 15. ALA4015054 A Clearance in dog blood at 4 umol/kg, iv or 10 umol/kg, po Canis lupus familiaris 1 organism-based format Scientific Literature 16. ALA4015055 A Volume of distribution at steady state in mouse blood at 5 umol/kg, iv or 30 umol/kg, po Mus musculus 2 organism-based format Scientific Literature 17. ALA4015056 A Volume of distribution at steady state in dog blood at 4 umol/kg, iv or 10 umol/kg, po Canis lupus familiaris 1 organism-based format Scientific Literature 18. ALA4015057 A Oral bioavailability in mouse blood at 30 umol/kg Mus musculus 2 organism-based format Scientific Literature 19. ALA4015058 A Oral bioavailability in dog blood at 10 umol/kg Canis lupus familiaris 1 organism-based format Scientific Literature 20. ALA4015059 A Fraction unbound in mouse plasma Mus musculus 1 cell-free format Scientific Literature