| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4026559 | B | Displacement of [3H]T-3364366 from D5D in rat liver microsomal membrane preincubated for 15 mins followed by radioligand addition measured after 150 mins by TopCount microscintillation counting assay | Rattus norvegicus | 21 | cell membrane format | Scientific Literature | ||
| 2. | ALA4026560 | B | Inhibition of D5D in human HepG2 cells assessed as [14C]AA formation from [14C]DGLA preincubated for 30 mins followed by [14C]eicosatrienoic acid addition measured after 3 hrs by TLC analysis | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 3. | ALA4026561 | A | Metabolic stability in human liver microsomes | Homo sapiens | 11 | assay format | Scientific Literature | ||
| 4. | ALA4026562 | A | Metabolic stability in mouse liver microsomes | Mus musculus | 11 | assay format | Scientific Literature | ||
| 5. | ALA4026563 | A | Drug metabolism in human hepatocytes assessed as 5-(4-fluorophenyl)-3-(3-hydroxyphenyl)oxazolidin-2-one formation by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4026564 | A | Drug metabolism in human hepatocytes assessed as 3-(5-(4-fluorophenyl)-2-oxooxazolidin-3-yl)phenyl hydrogen sulfate formation by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4026565 | A | Drug metabolism in human hepatocytes assessed as (2S,3S,4S,5R,6S)-6-(5-(4-fluorophenyl)-3-(3-methoxyphenyl)-2-oxooxazolidin-4-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid formation by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4026566 | A | Drug metabolism in human hepatocytes assessed as (2S,3S,4S,5R,6S)-6-(3-(5-(4-fluorophenyl)-2-oxooxazolidin-3-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid formation by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4026567 | A | Drug metabolism in human hepatocytes assessed as 5-(4-fluorophenyl)-4-hydroxy-3-(3-methoxyphenyl)oxazolidin-2-one formation by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4026568 | A | Drug metabolism in human hepatocytes assessed as 3-(5-(4-fluorophenyl)-4-hydroxy-2-oxooxazolidin-3-yl)phenyl hydrogen sulfate formation by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4026569 | A | Drug metabolism in mouse hepatocytes assessed as 5-(4-fluorophenyl)-3-(3-hydroxyphenyl)oxazolidin-2-one formation by LC-MS/MS analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4026570 | A | Drug metabolism in mouse hepatocytes assessed as 3-(5-(4-fluorophenyl)-2-oxooxazolidin-3-yl)phenyl hydrogen sulfate formation by LC-MS/MS analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4026571 | A | Drug metabolism in mouse hepatocytes assessed as (2S,3S,4S,5R,6S)-6-(5-(4-fluorophenyl)-3-(3-methoxyphenyl)-2-oxooxazolidin-4-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid formation by LC-MS/MS analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4026572 | A | Drug metabolism in mouse hepatocytes assessed as (2S,3S,4S,5R,6S)-6-(3-(5-(4-fluorophenyl)-2-oxooxazolidin-3-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid formation by LC-MS/MS analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4026573 | A | Drug metabolism in mouse hepatocytes assessed as 5-(4-fluorophenyl)-4-hydroxy-3-(3-methoxyphenyl)oxazolidin-2-one formation by LC-MS/MS analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4026574 | A | Drug metabolism in mouse hepatocytes assessed as 3-(5-(4-fluorophenyl)-4-hydroxy-2-oxooxazolidin-3-yl)phenyl hydrogen sulfate formation by LC-MS/MS analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4026575 | A | Drug metabolism in mouse liver assessed as 5-(4-fluorophenyl)-3-(3-hydroxyphenyl)oxazolidin-2-one formation at 488 mg/kg/day, po by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4026576 | A | Drug metabolism in mouse liver assessed as 3-(5-(4-fluorophenyl)-2-oxooxazolidin-3-yl)phenyl hydrogen sulfate formation at 488 mg/kg/day, po by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4026577 | A | Drug metabolism in mouse liver assessed as (2S,3S,4S,5R,6S)-6-(5-(4-fluorophenyl)-3-(3-methoxyphenyl)-2-oxooxazolidin-4-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid formation at 488 mg/kg/day, po by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4026578 | A | Drug metabolism in mouse liver assessed as (2S,3S,4S,5R,6S)-6-(3-(5-(4-fluorophenyl)-2-oxooxazolidin-3-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid formation at 488 mg/kg/day, po by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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