| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4021079 | B | Agonist activity at zebrafish VDR LBD (156 to 453 residues) expressed in HEK293 EBNA cells harboring human CYP24-Tk-Luc plasmid assessed as induction of CYP24a1 gene at 100 nM after 18 hrs by dual-luciferase transcriptional reporter gene assay | Danio rerio | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4021081 | B | Agonist activity at zebrafish VDR LBD (156 to 453 residues) expressed in HEK293 EBNA cells harboring human CYP24-Tk-Luc plasmid assessed as induction of CYP24a1 gene after 18 hrs by dual-luciferase transcriptional reporter gene assay | Danio rerio | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA4021082 | B | Agonist activity at zebrafish VDR LBD (156 to 453 residues) expressed in HEK293 EBNA cells harboring human CYP24-Tk-Luc plasmid assessed as induction of CYP24a1 gene at 1000 nM after 18 hrs by dual-luciferase transcriptional reporter gene assay relative to control | Danio rerio | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA4021083 | B | Agonist activity at VP16-fused human full length VDR expressed in COS7 cells assessed as coactivator Gal4 DBD-fused SRC-1 NRID recruitment at > 100 nM after 48 hrs by luciferase reporter gene assay based mammalian two-hybrid assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA4021084 | B | Agonist activity at VP16-fused human full length VDR expressed in COS7 cells assessed as coactivator Gal4 DBD-fused Med1 NRID recruitment at > 100 nM after 48 hrs by luciferase reporter gene assay based mammalian two-hybrid assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA4021085 | B | Agonist activity at VP16-fused human full length VDR expressed in COS7 cells assessed as corepressor Gal4 DBD-fused NCOR NRID release at 10 to 1000 nM after 48 hrs by luciferase reporter gene assay based mammalian two-hybrid assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4021086 | B | Agonist activity at VP16-fused human full length VDR expressed in COS7 cells assessed as corepressor Gal4 DBD-fused SMRT NRID release at 10 to 1000 nM after 48 hrs by luciferase reporter gene assay based mammalian two-hybrid assay | Homo sapiens | 3 | cell-based format | Scientific Literature |
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